Journal article
Double in situ hybridization in combination with digital image analysis: A new approach to study interphase chromosome topography
Abstract
Double in situ hybridization with mercurated and biotinylated chromosome specific DNA probes in combination with digital image analysis provides a new approach to compare the distribution of homologous and nonhomologous chromosome targets within individual interphase nuclei. Here we have used two DNA probes representing tandemly repeated sequences specific for the constitutive heterochromatin of the human chromosomes 1 and 15, respectively, and …
Authors
Emmerich P; Loos P; Jauch A; Hopman AHN; Wiegant J; Higgins MJ; White BN; Van Der Ploeg M; Cremer C; Cremer T
Journal
Experimental Cell Research, Vol. 181, No. 1, pp. 126–140
Publisher
Elsevier
Publication Date
March 1989
DOI
10.1016/0014-4827(89)90188-2
ISSN
0014-4827