Journal article
Genetic mapping of DNA segments relative to the locus for the fragile-X syndrome at Xq27.3.
Abstract
We have tested linkage between the locus for the fragile-X [fra(X)] syndrome at Xq27.3 and five polymorphic restriction sites identified by four DNA probes mapping distal to Xq26.1. A maximum distance of approximately 15 centimorgans (cM) between Xq27.3 and the marker loci mapping to this region was predicted based on the physical chromosome length. Close linkage between the disease and marker loci was excluded for probes DXS19 and DXS37 (theta …
Authors
Mulligan LM; Phillips MA; Forster-Gibson CJ; Beckett J; Partington MW; Simpson NE; Holden JJ; White BN
Journal
American Journal of Human Genetics, Vol. 37, No. 3, pp. 463–472
Publication Date
May 1985
ISSN
0002-9297