Journal article
Localization of X-Linked Dominant Charcot-Marie-Tooth Disease (CMT 2) to Xq13
Abstract
A family is described in which Charcot-Marie-Tooth disease is inherited as an X-linked dominant mutation (CMT2). Ten DNA marker loci on the X chromosome were used to map the disease locus by linkage analysis. The DXYS1 sequence at Xq13 was found to be linked to the CMT2 locus at an estimated distance of 6 cM (Zmax = 2.87 at theta max = 0.06). The data also suggested close linkage of the CMT2 locus to PGK1 (Zmax = 1.51 at theta max = 0) which …
Authors
Beckett J; Holden JJA; Simpson NE; White BN; Macleod PM
Journal
Journal of Neurogenetics, Vol. 3, No. 4, pp. 225–231
Publisher
Taylor & Francis
Publication Date
January 1986
DOI
10.3109/01677068609106852
ISSN
0167-7063