Non-coding RNAs as antibiotic targets Journal Articles

abstract

• Antibiotics inhibit a wide range of essential processes in the bacterial cell, including replication, transcription, translation and cell wall synthesis. In many instances, these antibiotics exert their effects through association with non-coding RNAs. This review highlights many classical antibiotic targets (e.g. rRNAs and the ribosome), explores a number of emerging targets (e.g. tRNAs, RNase P, riboswitches and small RNAs), and discusses the future directions and challenges associated with non-coding RNAs as antibiotic targets.

authors

• Colameco, Savannah
• Elliot, Marie

status

• published 

publication date

• June 2017

has subject area

• 0601 Biochemistry and Cell Biology (FoR)
• 1115 Pharmacology and Pharmaceutical Sciences (FoR)
• Animals (MeSH)
• Anti-Bacterial Agents (MeSH)
• Drug Delivery Systems (MeSH)
• Humans (MeSH)
• Pharmacology & Pharmacy (Science Metrix)
• RNA, Transfer (MeSH)
• RNA, Untranslated (MeSH)
• Riboswitch (MeSH)

published in

• Biochemical Pharmacology  Journal

keywords

• Animals
• Anti-Bacterial Agents
• Antibiotic
• Drug Delivery Systems
• Humans
• Non-coding RNA
• RNA, Transfer
• RNA, Untranslated
• Ribosome
• Riboswitch
• tRNA

Digital Object Identifier (DOI)

• 10.1016/j.bcp.2016.12.015

PubMed ID

• 28012959

start page

• 29

end page

• 42

volume

• 133