Transgene-induced production of IL-4 alters the development and collagen expression of Th1 type pulmonary granulomas

A number of complex mechanisms regulate the size and ceuularity of granulomatous reaction, particularly cytokine production profiles. The formation of Th1 type lesions consist of primarily mononuclear cells, whereas Th2 type granulomas have an additional eosinophil component and appear to become more fibrotic. In the present study, Th1 (purified protein derivative; PPD) and Th2 (Schistosome egg antigen; SEA) type granulomas were established to …