Programming the detection limits of biosensors through controlled nanostructuring

Advances in materials chemistry offer a range of nanostructured shapes and textures for building new biosensors1,2,3,4,5,6,7,8,9,10. Previous reports have implied that controlling the properties of sensor substrates can improve detection sensitivities, but the evidence remains indirect11,12,13. Here we show that by nanostructuring the sensing electrodes, it is possible to create nucleic acid sensors that have a broad range of sensitivities and …