Journal article
In Vitro and In Vivo Evaluation of Novel Ciprofloxacin-Releasing Silicone Hydrogel Contact LensesCiprofloxacin-Releasing Contact Lenses
Abstract
PURPOSE: The purpose of this study was to evaluate ciprofloxacin-releasing silicone hydrogel contact lens materials in vitro and in vivo for the treatment of microbial keratitis.
METHODS: Model silicone hydrogel contact lens materials were manufactured using a molecular imprinting technique to modify ciprofloxacin release kinetics. Various contact lens properties, including light transmission and surface wettability, were determined, and the in …
Authors
Hui A; Willcox M; Jones L
Journal
Investigative Ophthalmology & Visual Science, Vol. 55, No. 8, pp. 4896–4904
Publisher
Association for Research in Vision and Ophthalmology (ARVO)
Publication Date
August 8, 2014
DOI
10.1167/iovs.14-14855
ISSN
0146-0404
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsAnti-Bacterial AgentsCiprofloxacinCoated Materials, BiocompatibleContact Lenses, Extended-WearCorneaDelayed-Action PreparationsDisease Models, AnimalEquipment DesignEye Infections, BacterialHumansKeratitisPseudomonas InfectionsPseudomonas aeruginosaRabbitsSilicone ElastomersSpectrometry, Fluorescence