Journal article
A Genome-Wide Association Study to Identify Single-Nucleotide Polymorphisms for Acute Kidney Injury
Abstract
RATIONALE: Acute kidney injury is a common and severe complication of critical illness and cardiac surgery. Despite significant attempts at developing treatments, therapeutic advances to attenuate acute kidney injury and expedite recovery have largely failed.
OBJECTIVES: Identifying genetic loci associated with increased risk of acute kidney injury may reveal novel pathways for therapeutic development.
Authors
Zhao B; Lu Q; Cheng Y; Belcher JM; Siew ED; Leaf DE; Body SC; Fox AA; Waikar SS; Collard CD
Journal
American Journal of Respiratory and Critical Care Medicine, Vol. 195, No. 4, pp. 482–490
Publisher
American Thoracic Society
Publication Date
February 15, 2017
DOI
10.1164/rccm.201603-0518oc
ISSN
1073-449X
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Acute Kidney InjuryAdultAgedApolipoprotein L1ApolipoproteinsBiomarkersCardiac Surgical ProceduresCase-Control StudiesCritical IllnessFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHumansIntensive Care UnitsInterferon Regulatory Factor-2Lipoproteins, HDLMaleMiddle AgedPolymorphism, Single NucleotidePostoperative ComplicationsRisk FactorsStatistics, NonparametricT-Box Domain Proteins