IGF‐I improves excitation‐contraction coupling in skeletal muscle fibers of dystrophic mdx mice

The absence of dystrophin in Duchenne muscular dystrophy (DMD) causes progressive muscle wasting and possibly aberrant intracellular signaling including abnormal excitation‐contraction coupling (ECC) in skeletal muscle. Insulin‐like growth factor‐I (IGF‐I) is a potential therapy for DMD, and can alter ECC. We tested the hypothesis that muscle specific over‐expression of IGF‐I could ameliorate disruptions in ECC in muscle fibers from transgenic …