Disruption of IGF‐I/IGFBP interactions decreases contraction‐induced injury in dystrophic skeletal muscle

Duchenne muscular dystrophy (DMD) is caused by a lack of dystrophin, a structural protein thought to confer stability to skeletal muscle fibers. A lack of dystrophin results in an increased susceptibility to contraction‐induced (CI) injury. Insulin‐like growth factor‐I (IGF‐I) therapy has beneficial effects on muscle function in mdx mice, a model of DMD. The actions of IGF‐I are strongly modified by IGF binding proteins (IGFBPs). The IGF‐I …