Serial C reactive protein values predict sensitivity of organisms to empirical antibiotics in neonates: a nested case–control study

BACKGROUND: It is common clinical practice to repeat serum C reactive protein (CRP) estimation in the first 48 h after starting empirical antibiotics for neonatal sepsis. The change in CRP is believed to indicate whether the empirical antibiotics are appropriate or not, but there is little evidence to support this practice. METHODS: This was a nested case-control study on neonates with suspected sepsis (clinical signs+baseline CRP >10 mg/L). We …