Effects of sodium warfarin administered during pregnancy in mice

Fetal death and congenital malformations have been reported to occur following oral anticoagulant therapy during pregnancy. Therefore, a systematic study of the possibility of teratogenic and fetopathic effects of sodium warfarin was undertaken in mice. Sodium warfarin was administered to pregnant mice in single doses of 1, 2, 3, or 4 mg. per kilogram of body weight on one of Gestation Days 8, 9, 10, or 11. Maternal prothrombin times were …