Journal article
Administration of systemic matrix metalloproteinase inhibitors maintains bone mechanical integrity in adjuvant arthritis.
Abstract
OBJECTIVE: To evaluate the influence of systemic tetracycline derived antimetalloproteinase compounds on bone morphology and mechanical integrity.
METHODS: Male Lewis rats (n = 78) were randomly assigned to one of 10 groups, comprising controls, adjuvant arthritis (AA), and adjuvant arthritis with various combinations of 2 chemically modified, non-antimicrobial tetracycline derivatives (CMT3 or CMT8) with either of 2 nonsteroidal …
Authors
Zernicke RF; Wohl GR; Greenwald RA; Moak SA; Leng W; Golub LM
Journal
The Journal of Rheumatology, Vol. 24, No. 7, pp. 1324–1331
Publication Date
July 1997
ISSN
0315-162X