Journal article
Expression of Retrovirally Transduced IL-1 α in IL-6-Dependent B Cells: A Murine Model of Aggressive Multiple Myeloma
Abstract
Retroviral-mediated gene transfer was employed to introduce an IL-1 alpha cDNA into an IL-6-dependent murine B-cell line. Bone marrow metastases and bone lesions were frequently observed following intravenous injection of these B cells into syngeneic mice. Because the retroviral vector also contained the neomycin phosphotransferase gene, metastatic cells could be easily recovered from bone marrow by addition of G418 to the culture medium. …
Authors
Hawley TS; Lach B; Burns BF; May LT; Sehgal PB; Hawley RG
Journal
Growth Factors, Vol. 5, No. 4, pp. 327–338
Publisher
Taylor & Francis
Publication Date
January 1991
DOI
10.3109/08977199109000296
ISSN
0897-7194