Journal article
Flow Control Valves for Analytical Microfluidic Chips without Mechanical Parts Based on Thermally Responsive Monolithic Polymers
Abstract
Monolithic plugs of poly(N-isopropylacrylamide) cross-linked with 5% methylenebisacrylamide have been prepared by photoinitiated polymerization within the channel of a microfluidic device. The volume change associated with the polymer phase transition at its lower critical solution temperature of 32 degrees C allows both the rapid swelling and the deswelling of the monoliths enabling the polymer to close or open the channel as it functions as a …
Authors
Yu C; Mutlu S; Selvaganapathy P; Mastrangelo CH; Svec F; Fréchet JMJ
Journal
Analytical Chemistry, Vol. 75, No. 8, pp. 1958–1961
Publisher
American Chemical Society (ACS)
Publication Date
April 1, 2003
DOI
10.1021/ac026455j
ISSN
0003-2700