Journal article
Early and late changes in markers of aortic stiffness with breast cancer therapy
Abstract
BACKGROUND: Anthracyclines and trastuzumab are well recognised to cause cardiac toxicity. Further to their effects on left ventricular (LV) function, anthracyclines in particular are considered to cause negative arterial remodelling. Whether these changes reverse is unknown. In addition, whether trastuzumab causes specific effects on arterial remodelling is yet undetermined.
METHODS: Patients receiving these agents for treatment of breast …
Authors
Grover S; Lou PW; Bradbrook C; Cheong K; Kotasek D; Leong DP; Koczwara B; Selvanayagam JB
Journal
Internal Medicine Journal, Vol. 45, No. 2, pp. 140–147
Publisher
Wiley
Publication Date
February 2015
DOI
10.1111/imj.12645
ISSN
1444-0903
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AdultAgedAnthracyclinesAntibodies, Monoclonal, HumanizedAntineoplastic Combined Chemotherapy ProtocolsBiomarkersBreast NeoplasmsCardiovascular DiseasesCase-Control StudiesDose-Response Relationship, DrugFeasibility StudiesFemaleHumansMagnetic Resonance Imaging, CineMiddle AgedObserver VariationPulse Wave AnalysisReference ValuesReproducibility of ResultsRisk AssessmentTime FactorsTrastuzumabTreatment OutcomeVascular Stiffness