Double and triple neoplasms in endometrial carcinoma.

From 1968-1992 1503 endometrial carcinomas have been evaluated at Bad Trissl Clinic retrospectively. All double and triple carcinomas have been histologically recorded, doubtful cases have been excluded. Double malignomas that occurred within 6 months are termed simultaneous, all others are termed successive ones. Of 1503 endometrial carcinomas 163 (10.8%) were multiple tumors. Of these 100 (6.6%) occur together with breast cancer and 63 (4.2%) with other primary malignomas. 145 (9.6%) are double, 18 (1.2%) are triple malignomas. 10 precancerous cases (0.7%) have been included in the survey. The average latency period from the first to the second malignoma was 4.5 years. Patients with endometrial carcinoma run higher risks of secondary tumors. One out of 10 develops a double malignoma, one out of 100 a triple malignoma. The combination of endometrial and breast cancer occurs in 60% of cases, the combination of genital and breast cancer in nearly 80% of cases. After-care of endometrial carcinoma must also include early detection of potential double and triple malignomas.