Journal article
Estrogen Metabolism and Risk of Breast Cancer: A Prospective Study of the 2:16α-Hydroxyestrone Ratio in Premenopausal and Postmenopausal Women
Abstract
Experimental and clinical evidence suggests that 16alpha-hydroxylated estrogen metabolites, biologically strong estrogens, are associated with breast cancer risk, while 2-hydroxylated metabolites, with lower estrogenic activity, are weakly related to this disease. This study analyzes the association of breast cancer risk with estrogen metabolism, expressed as the ratio of 2-hydroxyestrone to 16alpha-hydroxyestrone, in a prospective nested …
Authors
Muti P; Bradlow HL; Micheli A; Krogh V; Freudenheim JL; Schünemann HJ; Stanulla M; Yang J; Sepkovic DW; Trevisan M
Journal
Epidemiology, Vol. 11, No. 6, pp. 635–640
Publisher
Wolters Kluwer
Publication Date
November 2000
DOI
10.1097/00001648-200011000-00004
ISSN
1044-3983