Journal article
Effect Modification by Catalase Genotype Suggests a Role for Oxidative Stress in the Association of Hormone Replacement Therapy with Postmenopausal Breast Cancer Risk
Abstract
Catalase, a ubiquitous heme enzyme, catalyzes conversion of hydrogen peroxide to water and molecular oxygen, protecting cells from oxidative stress. A C/T polymorphism in the promoter region of the CAT gene (rs1001179) affects transcriptional activity and RBC catalase levels. Oxidative stress may explain the observed increased postmenopausal breast cancer risk associated with hormone replacement therapy (HRT). We examined CAT genotype, HRT, and …
Authors
Quick SK; Shields PG; Nie J; Platek ME; McCann SE; Hutson AD; Trevisan M; Vito D; Modali R; Lehman TA
Journal
Cancer Epidemiology Biomarkers & Prevention, Vol. 17, No. 5, pp. 1082–1087
Publisher
American Association for Cancer Research (AACR)
Publication Date
May 1, 2008
DOI
10.1158/1055-9965.epi-07-2755
ISSN
1055-9965
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AdultAgedBreast NeoplasmsCase-Control StudiesCatalaseChi-Square DistributionEffect Modifier, EpidemiologicEstrogen Replacement TherapyFemaleGenetic Predisposition to DiseaseGenotypeHumansLogistic ModelsMiddle AgedOxidative StressPolymorphism, GeneticPostmenopauseReceptors, EstrogenRisk AssessmentRisk Factors