Alexander Little - McMaster Experts

Affiliations

Faculty of Science, McMaster University
Assistant Professor, Biology, Faculty of Science
Assistant Professor of Biology, Queen's University,

Research Areas

Animal cell and molecular biology (RA)
Animal developmental and reproductive biology (RA)
Animal physiological ecology (RA)
Animal physiology, endocrinology (RA)
Animal physiology, environmental stress (RA)
Animal physiology, metabolism (RA)
Developmental genetics (including sex determination) (RA)
Ecotoxicology (RA)
Epigenetics and epigenomics (RA)
Gene regulation and expression (RA)
Global change biology (RA)
Invertebrate biology (RA)
Molecular genetics (RA)
Thermoregulation (RA)
Vertebrate biology (RA)

Scholarly Activity in McMaster Experts

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Co-investigator Network

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selected scholarly activity

chapters
- Local Regulation of Thyroid Hormone Signaling. Vitamins and Hormones. 1-17. 2018
- Amphibian and Reptile Adaptations to the Environment. 41-62. 2017
journal articles
- Endocrine responses to environmental variation. Philosophical Transactions of the Royal Society of London. Biological Sciences. 379:20220515. 2024
- Thyroid hormone links environmental signals to DNA methylation. Philosophical Transactions of the Royal Society of London. Biological Sciences. 379:20220506. 2024
- Correction: Behavioral and physiological evidence that increasing group size ameliorates the impacts of social disturbance. Journal of Experimental Biology. 227:jeb246900. 2024
- Impacts of sequential salinity and heat stress are recovery time-specific in freshwater crustacean, Daphnia pulicaria. Ecotoxicology and Environmental Safety. 269:115899-115899. 2024
- Low Glycolysis Is Neuroprotective during Anoxic Spreading Depolarization (SD) and Reoxygenation in Locusts. eNeuro. 10:ENEURO.0325-23.2023. 2023
- Evaluating cardiac oxygen limitation as a mechanism for female-biased mortality in coho salmon (Oncorhynchus kisutch). Canadian Journal of Zoology. 101:163-171. 2023
- Metabolic cost of osmoregulation by the gastro-intestinal tract in marine teleost fish. Frontiers in Physiology. 14:1163153. 2023
- Naphthenic acid fraction compounds reduce the reproductive success of wood frogs (Rana sylvatica) by affecting offspring viability. Environmental Pollution. 316:120455-120455. 2023
- Corrigendum to: Sex-specific differences in swimming, aerobic metabolism and recovery from exercise in adult coho salmon (Oncorhynchus kisutch) across ecologically relevant temperatures. Conservation Physiology. 10:coab100. 2022
- DNA methyltransferase 3a mediates developmental thermal plasticity. Journal of Biology. 19:11. 2021
- Withdrawal notice to “Utilizing comparative models in biomedical research” [Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, Volume 255, 2021, 110593, 10.1016/j.cbpb.2021.110593]. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. 259:110987-110987. 2021
- Thyroid hormone regulation of thermal acclimation in ectotherms: Physiological mechanisms and ecoevolutionary implications. Molecular and Cellular Endocrinology. 530:111285-111285. 2021
- WITHDRAWN: Utilizing comparative models in biomedical research.. Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology. 256:110938. 2021
- Physiological Performance Curves: When Are They Useful?. Frontiers in Physiology. 12:805102. 2021
- Plasticity of Performance Curves in Ectotherms: Individual Variation Modulates Population Responses to Environmental Change. Frontiers in Physiology. 12:733305. 2021
- What do warming waters mean for fish physiology and fisheries?. Journal of Fish Biology. 97:328-340. 2020
- Reduced lactate dehydrogenase activity in the heart and suppressed sex hormone levels are associated with female-biased mortality during thermal stress in Pacific salmon. Journal of Experimental Biology. 223:jeb214841. 2020
- Behavioral and physiological evidence that increasing group size ameliorates the impacts of social disturbance. Journal of Experimental Biology. 223:jeb217075. 2020
- Maxed Out: Optimizing Accuracy, Precision, and Power for Field Measures of Maximum Metabolic Rate in Fishes. Physiological and Biochemical Zoology. 93:243-254. 2020
- Sex-specific differences in swimming, aerobic metabolism and recovery from exercise in adult coho salmon (Oncorhynchus kisutch) across ecologically relevant temperatures. Conservation Physiology. 9:coab016. 2020
- Population differences in aggression are shaped by tropical cyclone-induced selection. Nature Ecology and Evolution. 3:1294-1297. 2019
- Call-to-Action: A Global Consortium for Tropical Cyclone Ecology. Trends in Ecology and Evolution. 34:588-590. 2019
- Predictors of staging accuracy, pathologic nodal involvement, and overall survival for cT2N0 carcinoma of the esophagus. Journal of Thoracic and Cardiovascular Surgery. 157:1264-1272.e6. 2019
- Comparative biochemistry of cytochrome c oxidase in animals. Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology. 224:170-184. 2018
- Sound the alarm: motorboat disturbance to fish embryos depends on engine type. Conservation Physiology. 6:coy064. 2018
- Plasticity of Performance Curves Can Buffer Reaction Rates from Body Temperature Variation in Active Endotherms. Frontiers in Physiology. 8:575. 2017
- Thermal conditions experienced during differentiation affect metabolic and contractile phenotypes of mouse myotubes. American Journal of Physiology. Regulatory Integrative and Comparative Physiology. 311:R457-R465. 2016
- A review of the peripheral levels of regulation by thyroid hormone. Journal of Comparative Physiology B: Biochemical, Systemic, and Environmental Physiology. 186:677-688. 2016
- Thyroid hormone influences muscle mechanics in carp (Cyprinus carpio) independently from SERCA activity. Journal of Experimental Biology. 219:2806-2808. 2016
- Skeletal muscle contractile function predicts activity and behaviour in zebrafish. Journal of Experimental Biology. 218:3878-3884. 2015
- Temperature determines toxicity: Bisphenol A reduces thermal tolerance in fish. Environmental Pollution. 197:84-89. 2015
- Generalist–specialist trade-off during thermal acclimation. Royal Society Open Science. 2:140251-140251. 2015
- Early effects of ageing on the mechanical performance of isolated locomotory (EDL) and respiratory (diaphragm) skeletal muscle using the work-loop technique. American Journal of Physiology. Regulatory Integrative and Comparative Physiology. 307:R670-R684. 2014
- The evolution of endothermy is explained by thyroid hormone-mediated responses to cold in early vertebrates. Journal of Experimental Biology. 217:1642-1648. 2014
- Thyroid hormone regulates cardiac performance during cold acclimation in Zebrafish (Danio rerio). Journal of Experimental Biology. 217:718-725. 2014
- Regulation of thermal acclimation varies between generations of the short‐lived mosquitofish that developed in different environmental conditions. Functional Ecology. 28:137-148. 2014
- Thyroid hormone actions are temperature-specific and regulate thermal acclimation in zebrafish (Danio rerio). Journal of Biology. 11:26. 2013
- Thyroid hormone regulates muscle function during cold acclimation in zebrafish (Danio rerio). Journal of Experimental Biology. 216:3514-3521. 2013
- Evolution of mitochondrial-encoded cytochrome oxidase subunits in endothermic fish: The importance of taxon-sampling in codon-based models. Molecular Phylogenetics and Evolution. 63:679-684. 2012
- Evolutionary affinity of billfishes (Xiphiidae and Istiophoridae) and flatfishes (Plueronectiformes): Independent and trans-subordinal origins of endothermy in teleost fishes. Molecular Phylogenetics and Evolution. 56:897-904. 2010
- Evolution of the nuclear-encoded cytochrome oxidase subunits in vertebrates. Physiological Genomics. 42:76-84. 2010
- Developmental Plasticity, Within-Generation Diversified Bet-hedging, and Robustness: what does it mean to be unstable?. Journal of Experimental Biology.
- Evolution of hypoxia responsive cytochrome c oxidase genes in vertebrates. The FASEB Journal. 25:858.10-858.10.
- Impacts of sequential salinity and heat stress are recovery time-specific in freshwater crustacean, Daphnia pulicaria. Ecotoxicology and Environmental Safety.
other
- Correction for: Behavioral and physiological evidence that increasing group size ameliorates the impacts of social disturbance HM Anderson, AG Little, DN Fisher, BL McEwen, BM Culbert, S Balshine, J.N. Pruitt Journal of Experimental Biology 223 (14), jeb217075
preprints
- Behavioral and physiological evidence that increasing group size ameliorates the impacts of social disturbance 2019
- Population differences in aggression are shaped by cyclone-induced selection 2019
presentations