selected scholarly activity
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chapters
- Multivariate Statistical Process Control and Process Control, Using Latent Variables. 275-303. 2020
- PHARMACEUTICAL MANUFACTURING: THE ROLE OF MULTIVARIATE ANALYSIS IN DESIGN SPACE, CONTROL STRATEGY, PROCESS UNDERSTANDING, TROUBLESHOOTING, AND OPTIMIZATION. 601-629. 2019
- Analysis, Monitoring, Control and Optimization of Batch Processes. 43-76. 2011
- Pharmaceutical Manufacturing: The Role of Multivariate Analysis in Design Space, Control Strategy, Process Understanding, Troubleshooting, and Optimization. 853-878. 2010
- 4.02 Multivariate Statistical Process Control and Process Control, Using Latent Variables. 21-54. 2009
- Multivariate Statistical Process Control and Process Control, Using Latent Variables. 21-54. 2009
- Turbidimetry in Particle Size Analysis 2000
- MULTIVARIATE STATISTICAL PROCESS CONTROL OF BATCH PROCESSES USING PCA AND PLS. 523-528. 1994
- Submicron particle size distribution determination using light scattering and particle chromatography. Evaluation of the techniques and their application to on-line measurements. 69-80. 1988
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conferences
- Quality by design in the pharmaceutical industry: Process modelling, monitoring and control using latent variable methods. IFAC Proceedings Volumes (IFAC-PapersOnline). 36-41. 2009
- Multivariate methods for the analysis of data-bases, process monitoring, and control in the material processing industries. IFAC Proceedings Volumes (IFAC-PapersOnline). 193-200. 2007
- Optimization of Batch Operating Policies. Part I. Handling Multiple Solutions#. Industrial & Engineering Chemistry Research. 7856-7866. 2006
- Optimization of batch processes using data driven latent variable models. AIChE Annual Meeting, Conference Proceedings. 12950. 2005
- Abnormal situation detection in batch processes utilizing projection methods. challenges for pharmaceutical applications. AIChE Annual Meeting, Conference Proceedings. 8175-8180. 2004
- Multivariate Forecasting of Batch Evolution for Monitoring and Fault Detection. IFAC-PapersOnLine. 71-76. 2004
- Multivariate monitoring of startups, restarts and grade transitions using projection methods. Proceedings of the American Control Conference. 5423-5426. 2003
- Comparing alternative approaches for multivariate statistical analysis of batch process data. Journal of Chemometrics. 397-413. 1999
- Multivariate statistical treatment of historical data for productivity and quality improvements. AIChE Symposium Series. 31-41. 1998
- Projection methods for process analysis and statistical process control: examples and experiences from industrial applications. Annual Quality Congress Transactions. 73-77. 1998
- Use of speech recognition methods and other techniques to address practical issues when using projection methods for modeling chemical processes.. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 366-COMP. 1997
- Experiences with industrial applications of projection methods for multivariate statistical process control. Computers and Chemical Engineering. S745-S750. 1996
- Analysis, monitoring and fault diagnosis of batch processes using multiblock and multiway PLS. Journal of Process Control. 277-284. 1995
- Process analysis, monitoring and diagnosis, using multivariate projection methods. Chemometrics and Intelligent Laboratory Systems. 3-21. 1995
- Statistical process control of multivariate processes. Control Engineering Practice. 403-414. 1995
- MULTIVARIATE IDENTIFICATION: A STUDY OF SEVERAL METHODS. IFAC Symposia Series. 101-107. 1992
- ONLINE LATEX PARTICLE-SIZE DETERMINATION BY DYNAMIC LIGHT-SCATTERING - DESIGN FOR AN INDUSTRIAL-ENVIRONMENT. PARTICLE SIZE DISTRIBUTION II. 86-97. 1991
- PARTICLE-SIZE DETERMINATION USING TURBIDIMETRY - CAPABILITIES, LIMITATIONS, AND EVALUATION FOR ONLINE APPLICATIONS. PARTICLE SIZE DISTRIBUTION II. 34-63. 1991
- TURBIDIMETRIC TECHNIQUES - CAPABILITY TO PROVIDE THE FULL PARTICLE-SIZE DISTRIBUTION. PARTICLE SIZE DISTRIBUTION II. 2-19. 1991
- PARTICLE-SIZE DETERMINATION USING TURBIDIMETRY - CAPABILITIES, LIMITATIONS AND EVALUATION FOR ONLINE APPLICATIONS. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 61-PMSE. 1990
- REMOTE SENSOR FOR FAST, ACCURATE ONLINE SUBMICRON PARTICLE SIZING OF SYNTHETIC-POLYMER EMULSIONS. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 64-PMSE. 1990
- ONLINE PARTICLE-SIZE DETERMINATION DURING LATEX PRODUCTION USING DYNAMIC LIGHT-SCATTERING. POLYMER CHARACTERIZATION. 105-123. 1990
- Particle size determination using turbidimetry. Capabilities, limitations and evaluation for on-line applications. Polymeric Materials Science and Engineering. 301-305. 1990
- Remote sensor for fast, accurate online submicron particle sizing of synthetic polymer emulsions. Polymeric Materials Science and Engineering. 317-322. 1990
- On-line particle size determination in a latex reactor using dynamic light scattering. Polymeric Materials Science and Engineering. 160-164. 1988
- Study of particle nucleation and growth in the absence of soap micelles during the emulsion polymerization of vinyl acetate in a pilot plant reactor. Polymeric Materials Science and Engineering. 1151-1155. 1988
- A STUDY OF PARTICLE NUCLEATION AND GROWTH IN THE ABSENCE OF SOAP MICELLES DURING THE EMULSION POLYMERIZATION OF VINYL-ACETATE IN A PILOT-PLANT REACTOR. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 244-PMSE. 1988
- ONLINE PARTICLE-SIZE DETERMINATION IN A LATEX REACTOR BY DYNAMIC LIGHT-SCATTERING. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 36-PMSE. 1988
- SUB-MICRON PARTICLE-SIZE DISTRIBUTION DETERMINATION USING LIGHT-SCATTERING AND PARTICLE CHROMATOGRAPHY - EVALUATION OF THE TECHNIQUES AND THEIR APPLICATION TO ONLINE MEASUREMENTS. CIM Bulletin. 66-66. 1988
- MEASUREMENT OF PARTICLE SIZE DISTRIBUTION OF LATEX PARTICLES IN THE SUBMICRON RANGE USING SIZE EXCLUSION CHROMATOGRAPHY AND TURBIDITY SPECTRA.. Polymeric Materials Science and Engineering Proceedings of the ACS Division of Polymeric Material. 147-151. 1985
- MEASUREMENT OF PARTICLE-SIZE DISTRIBUTION OF LATEX-PARTICLES IN THE SUB-MICRON RANGE USING SIZE EXCLUSION CHROMATOGRAPHY AND TURBIDITY SPECTRA. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 31-PME. 1985
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journal articles
- Continuous manufacturing. Pharmaceutical Engineering. 37:35-42. 2017
- Scientific and regulatory considerations for implementing mathematical models in the quality by design (QbD) framework (part 2). Pharmaceutical Engineering. 35:38-51. 2015
- Scientific and regulatory considerations for implementing mathematical models in the quality by design (QbD) framework. Pharmaceutical Engineering. 35:80-88. 2015
- Multivariate Analysis for Process Understanding, Monitoring, Control, and Optimization of Lyophilization Processes. AAPS Advances in the Pharmaceutical Sciences Series. 18:537-564. 2015
- Scientific and regulatory considerations for implementing mathematical models in the quality by design (QbD) framework. Pharmaceutical Engineering. 34. 2014
- Preface to John MacGregor Festschrift. Industrial & Engineering Chemistry Research. 52:12253-12257. 2013
- The business benefits of quality by design (QbD). Pharmaceutical Engineering. 32:52-62. 2012
- Quality by design in the pharmaceutical industry: The role of multivariate analysis. American Pharmaceutical Review. 12. 2009
- Quality by Design in the Pharmaceutical Industry: Process Modelling, Monitoring and Control using Latent Variable Methods. IFAC-PapersOnLine. 42:36-41. 2009
- MULTIVARIATE METHODS FOR THE ANALYSIS OF DATA-BASES, PROCESS MONITORING, AND CONTROL IN THE MATERIAL PROCESSING INDUSTRIES. IFAC-PapersOnLine. 40:193-198. 2007
- Process Analytical Technology Beyond Real-Time Analyzers: The Role of Multivariate Analysis. Critical Reviews in Analytical Chemistry. 36:257-278. 2006
- The Process Analytical Technology initiative and multivariate process analysis, monitoring and control. Analytical and Bioanalytical Chemistry. 384:1043-1048. 2006
- Product transfer between sites using Joint-Y PLS. Chemometrics and Intelligent Laboratory Systems. 79:101-114. 2005
- Application of latent variable methods to process control and multivariate statistical process control in industry. International Journal of Adaptive Control and Signal Processing. 19:213-246. 2005
- Abnormal situation detection and projection methods—industrial applications. October 28–29, 2003. Hamilton, Ontario, Canada. Chemometrics and Intelligent Laboratory Systems. 76:215-220. 2005
- Model Predictive Monitoring for Batch Processes. Industrial & Engineering Chemistry Research. 43:5929-5941. 2004
- Troubleshooting of an Industrial Batch Process Using Multivariate Methods. Industrial & Engineering Chemistry Research. 42:3592-3601. 2003
- Abnormal Situation Detection, Three Way Data and Projection Methods; Robust Modeling for Industrial Applications. IFAC-PapersOnLine. 36:555-560. 2003
- Editorial Professor John F. MacGregor: a pioneer of multivariate statistical process control and recipient of the fourth Herman Wold medal. Journal of Chemometrics. 17:1-4. 2003
- Abnormal situation detection, three-way data and projection methods; robust data archiving and modeling for industrial applications. Annual Reviews in Control. 27:131-139. 2003
- Multivariate dynamic data modeling for analysis and statistical process control of batch processes, start‐ups and grade transitions. Journal of Chemometrics. 17:93-109. 2003
- Assessing problem-solving skills part 2: Assessing the process of problem solving. Chemical Engineering Education. 36:60-67. 2002
- Multivariate SPC for startups and grade transitions. AIChE Journal. 48:2890-2901. 2002
- Process analysis and abnormal situation detection: from theory to practice. IEEE Control Systems Magazine. 22:10-25. 2002
- An investigation of orthogonal signal correction algorithms and their characteristics. Journal of Chemometrics. 16:176-188. 2002
- Assessing Problem-Solving Skills. Part I: The Context for Assessment. Chemical Engineering Education. 35:300-307. 2001
- Analysis of multiblock and hierarchical PCA and PLS models. Journal of Chemometrics. 12:301-321. 1998
- Multivariate SPC Methods for Process and Product Monitoring. Journal of Quality Technology. 28:409-428. 1996
- Analysis, Monitoring and Fault Diagnosis of Industrial Processes Using Multivariate Statistical Projection Methods. IFAC-PapersOnLine. 29:5941-5946. 1996
- Multivariate Statistical Process Control of Batch Processes Using PCA and PLS. IFAC-PapersOnLine. 27:523-528. 1994
- Multivariate identification: a study of several methods. undefined. 1992
- ONLINE LATEX PARTICLE-SIZE DETERMINATION BY DYNAMIC LIGHT-SCATTERING - DESIGN FOR AN INDUSTRIAL-ENVIRONMENT. ACS Symposium Series. 472:86-97. 1991
- PARTICLE-SIZE DETERMINATION USING TURBIDIMETRY - CAPABILITIES, LIMITATIONS, AND EVALUATION FOR ONLINE APPLICATIONS. ACS Symposium Series. 472:34-63. 1991
- TURBIDIMETRIC TECHNIQUES - CAPABILITY TO PROVIDE THE FULL PARTICLE-SIZE DISTRIBUTION. ACS Symposium Series. 472:2-19. 1991
- ONLINE PARTICLE-SIZE DETERMINATION DURING LATEX PRODUCTION USING DYNAMIC LIGHT-SCATTERING. Advances in Chemistry Series. 105-123. 1990
- Minimum number of turbidity measurements required for the determination of particle size distributions. Journal of Colloid and Interface Science. 120:292-295. 1987
- On-line Particle Size and Conversion Determination in Continuous Latex Reactor Trains. IFAC-PapersOnLine. 20:217-222. 1987
- Measuring Particle Size Distribution of Latex Particles in the Submicrometer Range Using Size-Exclusion Chromatography and Turbidity Spectra. ACS Symposium Series. 332:242-255. 1987
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theses