selected scholarly activity
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chapters
- Multivariate Statistical Process Control and Process Control, Using Latent Variables. 275-303. 2020
- PHARMACEUTICAL MANUFACTURING: THE ROLE OF MULTIVARIATE ANALYSIS IN DESIGN SPACE, CONTROL STRATEGY, PROCESS UNDERSTANDING, TROUBLESHOOTING, AND OPTIMIZATION. 601-629. 2019
- Analysis, Monitoring, Control and Optimization of Batch Processes. 43-76. 2011
- Pharmaceutical Manufacturing: The Role of Multivariate Analysis in Design Space, Control Strategy, Process Understanding, Troubleshooting, and Optimization. 853-878. 2010
- 4.02 Multivariate Statistical Process Control and Process Control, Using Latent Variables. 21-54. 2009
- Multivariate Statistical Process Control and Process Control, Using Latent Variables. 21-54. 2009
- Turbidimetry in Particle Size Analysis 2000
- MULTIVARIATE STATISTICAL PROCESS CONTROL OF BATCH PROCESSES USING PCA AND PLS. 523-528. 1994
- Submicron particle size distribution determination using light scattering and particle chromatography. Evaluation of the techniques and their application to on-line measurements. 69-80. 1988
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conferences
- Quality by design in the pharmaceutical industry: Process modelling, monitoring and control using latent variable methods. IFAC Proceedings Volumes (IFAC-PapersOnline). 36-41. 2009
- Multivariate methods for the analysis of data-bases, process monitoring, and control in the material processing industries. IFAC Proceedings Volumes (IFAC-PapersOnline). 193-200. 2007
- Optimization of Batch Operating Policies. Part I. Handling Multiple Solutions#. Industrial & Engineering Chemistry Research. 7856-7866. 2006
- Optimization of batch processes using data driven latent variable models. AIChE Annual Meeting Conference Proceedings. 12950. 2005
- Abnormal situation detection in batch processes utilizing projection methods. challenges for pharmaceutical applications. AIChE Annual Meeting Conference Proceedings. 8175-8180. 2004
- Multivariate Forecasting of Batch Evolution for Monitoring and Fault Detection. IFAC-PapersOnLine. 71-76. 2004
- Multivariate monitoring of startups, restarts and grade transitions using projection methods. Proceedings of the American Control Conference. 5423-5426. 2003
- Comparing alternative approaches for multivariate statistical analysis of batch process data. Journal of Chemometrics. 397-413. 1999
- Multivariate statistical treatment of historical data for productivity and quality improvements. AIChE Symposium Series. 31-41. 1998
- Projection methods for process analysis and statistical process control: examples and experiences from industrial applications. Annual Quality Congress Transactions. 73-77. 1998
- Use of speech recognition methods and other techniques to address practical issues when using projection methods for modeling chemical processes.. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 366-COMP. 1997
- Experiences with industrial applications of projection methods for multivariate statistical process control. Computers and Chemical Engineering. S745-S750. 1996
- Analysis, monitoring and fault diagnosis of batch processes using multiblock and multiway PLS. Journal of Process Control. 277-284. 1995
- Process analysis, monitoring and diagnosis, using multivariate projection methods. Chemometrics and Intelligent Laboratory Systems. 3-21. 1995
- Statistical process control of multivariate processes. Control Engineering Practice. 403-414. 1995
- MULTIVARIATE IDENTIFICATION: A STUDY OF SEVERAL METHODS. IFAC Symposia Series. 101-107. 1992
- ONLINE LATEX PARTICLE-SIZE DETERMINATION BY DYNAMIC LIGHT-SCATTERING - DESIGN FOR AN INDUSTRIAL-ENVIRONMENT. PARTICLE SIZE DISTRIBUTION II. 86-97. 1991
- PARTICLE-SIZE DETERMINATION USING TURBIDIMETRY - CAPABILITIES, LIMITATIONS, AND EVALUATION FOR ONLINE APPLICATIONS. PARTICLE SIZE DISTRIBUTION II. 34-63. 1991
- TURBIDIMETRIC TECHNIQUES - CAPABILITY TO PROVIDE THE FULL PARTICLE-SIZE DISTRIBUTION. PARTICLE SIZE DISTRIBUTION II. 2-19. 1991
- PARTICLE-SIZE DETERMINATION USING TURBIDIMETRY - CAPABILITIES, LIMITATIONS AND EVALUATION FOR ONLINE APPLICATIONS. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 61-PMSE. 1990
- REMOTE SENSOR FOR FAST, ACCURATE ONLINE SUBMICRON PARTICLE SIZING OF SYNTHETIC-POLYMER EMULSIONS. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 64-PMSE. 1990
- ONLINE PARTICLE-SIZE DETERMINATION DURING LATEX PRODUCTION USING DYNAMIC LIGHT-SCATTERING. POLYMER CHARACTERIZATION. 105-123. 1990
- Particle size determination using turbidimetry. Capabilities, limitations and evaluation for on-line applications. Polymeric Materials Science and Engineering. 301-305. 1990
- Remote sensor for fast, accurate online submicron particle sizing of synthetic polymer emulsions. Polymeric Materials Science and Engineering. 317-322. 1990
- On-line particle size determination in a latex reactor using dynamic light scattering. Polymeric Materials Science and Engineering. 160-164. 1988
- Study of particle nucleation and growth in the absence of soap micelles during the emulsion polymerization of vinyl acetate in a pilot plant reactor. Polymeric Materials Science and Engineering. 1151-1155. 1988
- A STUDY OF PARTICLE NUCLEATION AND GROWTH IN THE ABSENCE OF SOAP MICELLES DURING THE EMULSION POLYMERIZATION OF VINYL-ACETATE IN A PILOT-PLANT REACTOR. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 244-PMSE. 1988
- ONLINE PARTICLE-SIZE DETERMINATION IN A LATEX REACTOR BY DYNAMIC LIGHT-SCATTERING. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 36-PMSE. 1988
- SUB-MICRON PARTICLE-SIZE DISTRIBUTION DETERMINATION USING LIGHT-SCATTERING AND PARTICLE CHROMATOGRAPHY - EVALUATION OF THE TECHNIQUES AND THEIR APPLICATION TO ONLINE MEASUREMENTS. CIM Bulletin. 66-66. 1988
- MEASUREMENT OF PARTICLE SIZE DISTRIBUTION OF LATEX PARTICLES IN THE SUBMICRON RANGE USING SIZE EXCLUSION CHROMATOGRAPHY AND TURBIDITY SPECTRA.. Polymeric Materials Science and Engineering. 147-151. 1985
- MEASUREMENT OF PARTICLE-SIZE DISTRIBUTION OF LATEX-PARTICLES IN THE SUB-MICRON RANGE USING SIZE EXCLUSION CHROMATOGRAPHY AND TURBIDITY SPECTRA. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 31-PME. 1985
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journal articles
- Continuous manufacturing. Pharmaceutical Engineering. 37:35-42. 2017
- Scientific and regulatory considerations for implementing mathematical models in the quality by design (QbD) framework (part 2). Pharmaceutical Engineering. 35:38-51. 2015
- Scientific and regulatory considerations for implementing mathematical models in the quality by design (QbD) framework. Pharmaceutical Engineering. 35:80-88. 2015
- Multivariate Analysis for Process Understanding, Monitoring, Control, and Optimization of Lyophilization Processes. AAPS Advances in the Pharmaceutical Sciences Series. 18:537-564. 2015
- Scientific and regulatory considerations for implementing mathematical models in the quality by design (QbD) framework. Pharmaceutical Engineering. 34. 2014
- Preface to John MacGregor Festschrift. Industrial & Engineering Chemistry Research. 52:12253-12257. 2013
- The business benefits of quality by design (QbD). Pharmaceutical Engineering. 32:52-62. 2012
- Quality by design in the pharmaceutical industry: The role of multivariate analysis. American Pharmaceutical Review. 12. 2009
- Quality by Design in the Pharmaceutical Industry: Process Modelling, Monitoring and Control using Latent Variable Methods. IFAC-PapersOnLine. 42:36-41. 2009
- MULTIVARIATE METHODS FOR THE ANALYSIS OF DATA-BASES, PROCESS MONITORING, AND CONTROL IN THE MATERIAL PROCESSING INDUSTRIES. IFAC-PapersOnLine. 40:193-198. 2007
- Process Analytical Technology Beyond Real-Time Analyzers: The Role of Multivariate Analysis. Critical Reviews in Analytical Chemistry. 36:257-278. 2006
- The Process Analytical Technology initiative and multivariate process analysis, monitoring and control. Analytical and Bioanalytical Chemistry. 384:1043-1048. 2006
- Product transfer between sites using Joint-Y PLS. Chemometrics and Intelligent Laboratory Systems. 79:101-114. 2005
- Application of latent variable methods to process control and multivariate statistical process control in industry. International Journal of Adaptive Control and Signal Processing. 19:213-246. 2005
- Abnormal situation detection and projection methods—industrial applications. October 28–29, 2003. Hamilton, Ontario, Canada. Chemometrics and Intelligent Laboratory Systems. 76:215-220. 2005
- Model Predictive Monitoring for Batch Processes. Industrial & Engineering Chemistry Research. 43:5929-5941. 2004
- Troubleshooting of an Industrial Batch Process Using Multivariate Methods. Industrial & Engineering Chemistry Research. 42:3592-3601. 2003
- Abnormal Situation Detection, Three Way Data and Projection Methods; Robust Modeling for Industrial Applications. IFAC-PapersOnLine. 36:555-560. 2003
- Editorial Professor John F. MacGregor: a pioneer of multivariate statistical process control and recipient of the fourth Herman Wold medal. Journal of Chemometrics. 17:1-4. 2003
- Abnormal situation detection, three-way data and projection methods; robust data archiving and modeling for industrial applications. Annual Reviews in Control. 27:131-139. 2003
- Multivariate dynamic data modeling for analysis and statistical process control of batch processes, start‐ups and grade transitions. Journal of Chemometrics. 17:93-109. 2003
- Assessing problem-solving skills part 2: Assessing the process of problem solving. Chemical Engineering Education. 36:60-67. 2002
- Multivariate SPC for startups and grade transitions. AIChE Journal. 48:2890-2901. 2002
- Process analysis and abnormal situation detection: from theory to practice. IEEE Control Systems Magazine. 22:10-25. 2002
- An investigation of orthogonal signal correction algorithms and their characteristics. Journal of Chemometrics. 16:176-188. 2002
- Assessing Problem-Solving Skills. Part I: The Context for Assessment. Chemical Engineering Education. 35:300-307. 2001
- Analysis of multiblock and hierarchical PCA and PLS models. Journal of Chemometrics. 12:301-321. 1998
- Multivariate SPC Methods for Process and Product Monitoring. Journal of Quality Technology. 28:409-428. 1996
- Analysis, Monitoring and Fault Diagnosis of Industrial Processes Using Multivariate Statistical Projection Methods. IFAC-PapersOnLine. 29:5941-5946. 1996
- Multivariate Statistical Process Control of Batch Processes Using PCA and PLS. IFAC-PapersOnLine. 27:523-528. 1994
- Multivariate identification: a study of several methods 1992
- ONLINE LATEX PARTICLE-SIZE DETERMINATION BY DYNAMIC LIGHT-SCATTERING - DESIGN FOR AN INDUSTRIAL-ENVIRONMENT. ACS Symposium Series. 472:86-97. 1991
- PARTICLE-SIZE DETERMINATION USING TURBIDIMETRY - CAPABILITIES, LIMITATIONS, AND EVALUATION FOR ONLINE APPLICATIONS. ACS Symposium Series. 472:34-63. 1991
- TURBIDIMETRIC TECHNIQUES - CAPABILITY TO PROVIDE THE FULL PARTICLE-SIZE DISTRIBUTION. ACS Symposium Series. 472:2-19. 1991
- ONLINE PARTICLE-SIZE DETERMINATION DURING LATEX PRODUCTION USING DYNAMIC LIGHT-SCATTERING. Advances in Chemistry Series. 105-123. 1990
- Minimum number of turbidity measurements required for the determination of particle size distributions. Journal of Colloid and Interface Science. 120:292-295. 1987
- On-line Particle Size and Conversion Determination in Continuous Latex Reactor Trains. IFAC-PapersOnLine. 20:217-222. 1987
- Measuring Particle Size Distribution of Latex Particles in the Submicrometer Range Using Size-Exclusion Chromatography and Turbidity Spectra. ACS Symposium Series. 332:242-255. 1987
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theses