selected scholarly activity
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chapters
- Optic Nerve Neoplasm. 67-83. 2023
- Venous Thromboembolism. 2196-2204. 2022
- Lens Extraction in PACG. 73-80. 2021
- Antiplatelet Drugs in the Management of Venous Thromboembolism, Cardioembolism, Ventricular Assist Devices, and Pregnancy Complications. 1067-1077. 2019
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conferences
- Comparison of YEARS and Adjust-Unlikely D-dimer Testing for Pulmonary Embolism in the Emergency Department. Annals of Emergency Medicine. 558-565. 2023
- Comparison of Peripapillary Vessel Density of Acute Nonarteritic Anterior Ischemic Optic Neuropathy and Other Optic Neuropathies With Disc Swelling Using Optical Coherence Tomography Angiography: A Pilot Study. Journal of Neuro-Ophthalmology. e470-e482. 2021
- Apixaban Versus Dalteparin for Thromboprophylaxis in Patients with Acute Spinal Cord Injury: A Pilot Study. Blood. 2434-2434. 2019
- DOES WARFARIN REALLY CAUSE ACUTE KIDNEY INJURY? A RETROSPECTIVE STUDY. American Journal of Hematology. E67-E67. 2018
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journal articles
- Colchicine for secondary prevention of vascular events: a meta-analysis of trials.. European Heart Journal. ehaf210. 2025
- Choosing the optimal oral anticoagulant for stroke prevention in atrial fibrillation: direct oral anticoagulants vs vitamin K antagonists.. Journal of Thrombosis and Haemostasis. 23:1207-1214. 2025
- Dosing Intensity of Anticoagulants for the Prevention and Treatment of Venous Thromboembolism and the Prevention of Stroke in Atrial Fibrillation: Why is There a Difference?. Seminars in Thrombosis and Hemostasis. 51:355-357. 2025
- Reticulocyte Production Index in Heart Failure: Refining Prognosis Beyond Current Risk Markers?. Canadian Journal of Cardiology. S0828-282X(25)00194-1. 2025
- Anticoagulants: From chance discovery to structure-based design.. Pharmacological Reviews. 77:100037. 2025
- Usual On-therapy Ranges of Drug Concentrations in Patients with Atrial Fibrillation Treated with Direct Oral Anticoagulants: A Systematic Review and Meta-analysis.. Thrombosis and Haemostasis. 2024
- Colchicine for secondary prevention of ischaemic stroke and atherosclerotic events: a meta-analysis of randomised trials.. EClinicalMedicine. 76:102835. 2024
- Developing a privacy-preserving deep learning model for glaucoma detection: a multicentre study with federated learning. British Journal of Ophthalmology. 108:1114-1123. 2024
- FRAIL-AF Study: More Bleeding With DOACs Compared With VKAs in Patients With Frailty?. Canadian Journal of Cardiology. 40:1377-1378. 2024
- FRAIL-AF Study: More Bleeding With DOACs Compared With VKAs in Patients With Frailty?. Canadian Journal of Cardiology. 40:1377-1378. 2024
- Prothrombin complex concentrate for emergency surgery in patients on oral Xa-inhibitors. Journal of Thrombosis and Haemostasis. 22:2761-2766. 2024
- Implementation, Clinical Benefit and Safety of a D-Dimer-Focused Pulmonary Embolism Testing Pathway in the Emergency Department. Annals of Emergency Medicine. 84:508-517. 2024
- Human papilloma virus and atherosclerotic cardiovascular disease. European Heart Journal. 45:1083-1085. 2024
- Glaucoma secondary to vascular changes in optic nerve head, retina, and choroid: abridged secondary publication.. Hong Kong Medical Journal. 30 Suppl 1:40-44. 2024
- Patterns and Persistence of Anticoagulant Use in the Treatment of Venous Thromboembolism: Insights from South Korea. Thrombosis and Haemostasis. 124:163-165. 2024
- Strategies to reduce out-of-pocket medication costs for Canadians with peripheral arterial disease. Canadian Journal of Surgery. 67:E1-E6. 2024
- Unresolved issues in the use of direct acting oral anticoagulants. Expert Review of Cardiovascular Therapy. 21:913-921. 2023
- Risk Factors for Venous Thromboembolism in Women of Childbearing Age. Thrombosis and Haemostasis. 123:1069-1071. 2023
- New Therapeutic Targets for the Prevention and Treatment of Venous Thromboembolism With a Focus on Factor XI Inhibitors. Arteriosclerosis, Thrombosis and Vascular Biology. 43:1755-1763. 2023
- Assessing Limb Outcomes in Drug Trials in Peripheral Artery Disease: The Need for a Universal and Pragmatic Definition. European Journal of Vascular and Endovascular Surgery. 66:442-443. 2023
- Testing for Hypercoagulability in Patients With Unexplained Arterial Thromboembolism. JACC: Case Reports. 20:101944-101944. 2023
- Routine measurement of DOAC concentrations for prognostication and clinical management in acute ischemic stroke: Is it ready for prime time?. European Journal of Internal Medicine. 113:18-19. 2023
- Recurrent Thrombosis and Bleeding in Patients with Cancer-Associated Venous Thromboembolism Receiving Anticoagulation: Are These Modifiable Risk Factors for Mortality?. Thrombosis and Haemostasis. 123:487-489. 2023
- Clinical Studies with Anticoagulants that Have Changed Clinical Practice. Seminars in Thrombosis and Hemostasis. 49:242-254. 2023
- In reply. Annals of Emergency Medicine. 81:517-518. 2023
- Risk of Normal Tension Glaucoma Progression From Automated Baseline Retinal-Vessel Caliber Analysis: A Prospective Cohort Study. American Journal of Ophthalmology. 247:111-120. 2023
- Impact of Rabeprazole on APO-Dabigatran Exposure in Healthy Volunteers. CJC OPEN. 5:1-7. 2023
- No apparent association between mRNA COVID-19 vaccination and venous thromboembolism. Blood Reviews. 56:100970-100970. 2022
- Optical coherence tomography angiography metrics predict normal tension glaucoma progression. Acta Ophthalmologica. 100:e1455-e1462. 2022
- Management of a Left Atrial Appendage Thrombus Due to Atrial Fibrillation Complicating Québec Platelet Disorder. Canadian Journal of Cardiology. 38:1464-1466. 2022
- Thromboprophylaxis After Hip or Knee Arthroplasty. Journal of the American Medical Association (JAMA). 328:712-712. 2022
- Neuro-Ophthalmic Literature Review. Neuro-Ophthalmology. 46:275-281. 2022
- Radiological Latency in Pineal Germinoma: A Case Report and Literature Review. Neuro-Ophthalmology. 46:264-269. 2022
- The Anti-Coronavirus Therapies (ACT) Trials: Design, Baseline Characteristics, and Challenges. CJC OPEN. 4:568-576. 2022
- Antithrombotic Therapy in Peripheral Artery Disease: Risk Stratification and Clinical Decision Making. Canadian Journal of Cardiology. 38:654-661. 2022
- Diagnostic assessment of glaucoma and non-glaucomatous optic neuropathies via optical texture analysis of the retinal nerve fibre layer. Nature Biomedical Engineering. 6:593-604. 2022
- Inflammation as a Mechanism and Therapeutic Target in Peripheral Artery Disease. Canadian Journal of Cardiology. 38:588-600. 2022
- Letter by de Vries et al Regarding Article “Off-Label Under- and Overdosing of Direct Oral Anticoagulants in Patients With Atrial Fibrillation: A Meta-Analysis”. Circulation. Cardiovascular Quality and Outcomes. 15:e008982. 2022
- Recommendations from the ICM-VTE: General. Journal of Bone and Joint Surgery. American volume. 104:4-162. 2022
- Ciraparantag as a potential universal anticoagulant reversal agent. European Heart Journal. 43:993-995. 2022
- Carbamazepine, phenytoin, and oral anticoagulants: Drug‐drug interaction and clinical events in a retrospective cohort. Research and Practice in Thrombosis and Haemostasis. 6:e12650-e12650. 2022
- Intraocular Pressure Control Predicts Retinal Nerve Fiber Layer Thinning in Primary Angle Closure Disease: The CUPAL Study. American Journal of Ophthalmology. 234:205-214. 2022
- Can a Single Measurement of Apixaban Levels Identify Patients at Risk of Overexposure? A Prospective Cohort Study. TH Open. 06:e10-e17. 2022
- Three-Dimensional Multi-Task Deep Learning Model to Detect Glaucomatous Optic Neuropathy and Myopic Features From Optical Coherence Tomography Scans: A Retrospective Multi-Centre Study. Frontiers in Medicine. 9:860574. 2022
- Characterization of macular choroid in normal‐tension glaucoma: a swept‐source optical coherence tomography study. Acta Ophthalmologica. 99:e1421-e1429. 2021
- Combined Phacoemulsification-Endoscopic Cyclophotocoagulation versus Phacoemulsification Alone in Primary Angle-Closure Glaucoma. Ophthalmology Glaucoma. 4:589-596. 2021
- In pregnant women with suspected VTE and low/intermediate or unlikely pretest probability, D-dimer rules out VTE at 3 mo. ACP journal club. 174:JC130-JC130. 2021
- Medical Therapy Following Urgent/Emergent Revascularization in Peripheral Artery Disease Patients (Canadian Acute Limb Ischemia Registry [CANALISE I]). CJC OPEN. 3:1325-1332. 2021
- Reply. Ophthalmology Glaucoma. 4:e10-e11. 2021
- Strategies for the prevention and treatment of bleeding in patients treated with dabigatran: an update. Expert Opinion on Drug Metabolism and Toxicology. 17:1091-1102. 2021
- Hypercoagulability and thrombosis in COVID-19: a modifiable cause for mortality?. European Heart Journal. 42:3143-3145. 2021
- Glaucoma as a Neurodegenerative Disease. Advances in Ophthalmology and Optometry. 6:263-274. 2021
- Prevention and Management of Urgent/Emergent Limb Ischemia. Current Cardiology Reports. 23:41. 2021
- Advances in the Management of Acute Venous Thromboembolism and New Therapeutic Agents. Seminars in Respiratory and Critical Care Medicine. 42:218-232. 2021
- Efficacy and safety of selective laser trabeculoplasty and pattern scanning laser trabeculoplasty: a randomised clinical trial. British Journal of Ophthalmology. 105:514-520. 2021
- A National Canadian Survey of Antithrombotic Therapy After Urgent and Emergent Limb Revascularization. Canadian Journal of Cardiology. 37:504-507. 2021
- Glaucoma as Neurodegeneration in the Brain. Eye and Brain. Volume 13:21-28. 2021
- Mortality Benefit in the Compass Trial: is It Related to Superior Statistical Power Or Better Efficacy and safety?. Future Cardiology. 17:175-182. 2021
- Plasma Rivaroxaban Level to Identify Patients at Risk of Drug Overexposure: Is a Single Measurement of Drug Level Reliable?. TH Open. 05:e84-e88. 2021
- Peripheral Oxygen Saturation in Older Persons Wearing Nonmedical Face Masks in Community Settings. Journal of the American Medical Association (JAMA). 324:2323-2323. 2020
- Plasma Apixaban Levels in Patients Treated Off Label With the Lower Dose. Journal of the American College of Cardiology. 76:2906-2907. 2020
- Global assessment of arteriolar, venular and capillary changes in normal tension glaucoma. Scientific Reports. 10:19222. 2020
- Direct oral anticoagulants: evidence and unresolved issues. The Lancet. 396:1767-1776. 2020
- Rivaroxaban for the Prevention of Major Adverse Cardiovascular Events in Patients with Coronary or Peripheral Artery Disease. Future Cardiology. 16:597-611. 2020
- Current Challenges in Diagnosis of Venous Thromboembolism. Journal of Clinical Medicine. 9:3509-3509. 2020
- Optic Disc Classification by Deep Learning versus Expert Neuro‐Ophthalmologists. Annals of Neurology. 88:785-795. 2020
- Apixaban for Stroke Prevention in Atrial Fibrillation: Why are Event Rates Higher in Clinical Practice than in Randomized Trials?—A Systematic Review. Thrombosis and Haemostasis. 120:1323-1329. 2020
- Prevention of Venous Thromboembolism in 2020 and Beyond. Journal of Clinical Medicine. 9:2467-2467. 2020
- COVID-19 coagulopathy, thrombosis, and bleeding. Blood. 136:381-383. 2020
- Intraocular pressure control and visual field changes in primary angle closure disease: the CUHK PACG Longitudinal (CUPAL) study. British Journal of Ophthalmology. 104:629-635. 2020
- Refining Risk Prediction for Recurrent Venous Thromboembolism: Can We Do Better?. Thrombosis and Haemostasis. 120:725-727. 2020
- Atypical presentations of intracranial dysgerminoma mimicking central nervous system inflammatory or demyelinating disease. Canadian Journal of Ophthalmology. 55:159-166. 2020
- Optimal Prescription of the Lower Dose of Apixaban. Journal of the American College of Cardiology. 75:1156-1158. 2020
- The conundrum of resuming anticoagulant therapy after intracerebral bleeding: In whom, when, and how?. Vascular Medicine. 25:60-62. 2020
- Novel antithrombotic strategies for treatment of venous thromboembolism. Blood. 135:351-359. 2020
- Recent advances in understanding, diagnosing and treating venous thrombosis. F1000Research. 9:1206-1206. 2020
- Thromboembolism in Older Adults. Frontiers in Medicine. 7:470016. 2020
- Fifty years of research on antithrombotic therapy: Achievements and disappointments. European Journal of Internal Medicine. 70:1-7. 2019
- Are Ticks the Answer to Medical Device-Associated Clotting?. Journal of the American College of Cardiology. 74:2190-2192. 2019
- Bleeding in patients with atrial fibrillation treated with combined antiplatelet and anticoagulant therapy: time to turn the corner. ANNALS OF TRANSLATIONAL MEDICINE. 7:S198-S198. 2019
- Response by Chan and Weitz to Letter Regarding Article, “Antithrombotic Agents: New Directions in Antithrombotic Therapy”. Circulation Research. 124:e119. 2019
- How I manage anticoagulant therapy in older individuals with atrial fibrillation or venous thromboembolism. Blood. 133:2269-2278. 2019
- Impact of Platelet Endothelial Aggregation Receptor-1 Genotypes on Platelet Reactivity and Early Cardiovascular Outcomes in Patients Undergoing Percutaneous Coronary Intervention and Treated With Aspirin and Clopidogrel. Circulation: Cardiovascular Interventions. 12:e007019. 2019
- Long-Term Management of Venous Thromboembolism: Lessons from EINSTEIN CHOICE and Other Extension Trials. Thrombosis and Haemostasis. 119:689-694. 2019
- AB023, A Novel Antibody That Binds Factor XI and Blocks Its Activation by Factor XIIa. Arteriosclerosis, Thrombosis and Vascular Biology. 39:533-535. 2019
- Reduction in Mortality following Elective Major Hip and Knee Surgery: A Systematic Review and Meta-Analysis. Thrombosis and Haemostasis. 119:668-674. 2019
- MAA868 locks factor XIa in a zymogen-like state. Blood. 133:1393-1394. 2019
- Rivaroxaban for Prevention and Treatment of Venous Thromboembolism. Future Cardiology. 15:63-77. 2019
- Utility of a Nurse-Led Pathway for Patients with Acute Venous Thromboembolism Discharged on Rivaroxaban: A Prospective Cohort Study. Seminars in Thrombosis and Hemostasis. 45:187-195. 2019
- Antithrombotic Agents. Circulation Research. 124:426-436. 2019
- Advances in Antithrombotic Therapy. Arteriosclerosis, Thrombosis and Vascular Biology. 39:7-12. 2019
- The Non-Vitamin K Antagonist Oral Anticoagulants in Heart Disease: Section V—Special Situations. Thrombosis and Haemostasis. 119:014-038. 2019
- The Role of Optical Coherence Tomography in the Acute Management of Neuro-Ophthalmic Diseases. Asia - Pacific Journal of Ophthalmology. 7:265-270. 2019
- In Vitro Reversal of the Anti-Aggregant Effect of Ticagrelor Using Untreated Platelets. Thrombosis and Haemostasis. 118:1895-1901. 2018
- Peak plasma concentration of direct oral anticoagulants in obese patients weighing over 120 kilograms: A retrospective study. Research and Practice in Thrombosis and Haemostasis. 2:684-688. 2018
- Proceedings of the Neuro-Ophthalmology Program of the 33rd Asia-Pacific Academy of Ophthalmology Congress, Hong Kong, 8–11 February 2018. Neuro-Ophthalmology. 42:326-333. 2018
- Quantifying immature platelets as markers of increased platelet production after coronary artery bypass grafting surgery. European Journal of Haematology. 101:362-367. 2018
- Factors Associated With Long-term Intraocular Pressure Fluctuation in Primary Angle Closure Disease: The CUHK PACG Longitudinal (CUPAL) Study. Journal of Glaucoma. 27:703-710. 2018
- Antiplatelet therapy in the management of atherothrombosis: recent clinical advances. Blood Advances. 2:1806-1806. 2018
- Neuro-Ophthalmic Literature Review. Neuro-Ophthalmology. 42:194-199. 2018
- Incidence and risk factors for acute kidney injury in patients with excessive anticoagulation on warfarin: a retrospective study. Journal of Thrombosis and Thrombolysis. 45:557-561. 2018
- Is there a role for pharmacokinetic/pharmacodynamic-guided dosing for novel oral anticoagulants?. American Heart Journal. 199:59-67. 2018
- Addressing the burden of hospital‐related venous thromboembolism: the role of extended anticoagulant prophylaxis. Journal of Thrombosis and Haemostasis. 16:413-417. 2018
- The value of novel oral anticoagulants in rural Australia. Medical Journal of Australia. 208:15-16. 2018
- Comparison of the ecarin chromogenic assay and diluted thrombin time for quantification of dabigatran concentrations. Journal of Thrombosis and Haemostasis. 15:2377-2387. 2017
- Is it an orbital foreign body?. Hong Kong Medical Journal. 23:653.e1-653.e2. 2017
- The use of optical coherence tomography in neuro-ophthalmology. Current Opinion in Ophthalmology. 28:552-557. 2017
- Immune thrombocytopenic purpura associated with fingolimod. BMJ Case Reports. 2017:bcr-2017-220590. 2017
- In high-risk patients with arthritis and previous upper GI bleeding, celecoxib vs naproxen reduced recurrent bleeding. ACP journal club. 167:JC17-JC17. 2017
- Platelet Transfusion for Ticagrelor Reversal. Circulation: Cardiovascular Interventions. 10:e005579. 2017
- Apixaban-Calibrated Anti-FXa Activity in Relation to Outcome Events and Clinical Characteristics in Patients with Atrial Fibrillation: Results from the AVERROES Trial. TH Open. 01:e139-e145. 2017
- Anticoagulation for Mechanical Heart Valves. Arteriosclerosis, Thrombosis and Vascular Biology. 37:743-745. 2017
- Once versus twice daily aspirin after coronary bypass surgery: a randomized trial. Journal of Thrombosis and Haemostasis. 15:889-896. 2017
- Optic Disc and Macular Imaging in Blind Eyes from Non-glaucomatous Optic Neuropathy: A Study with Spectral-domain Optical Coherence Tomography. Neuro-Ophthalmology. 41:1-6. 2017
- Measuring Dabigatran Levels: What Tests Are Available and What Still Needs to Be Done?. Thrombosis and Haemostasis. 117:2213-2214. 2017
- Rivaroxaban in treatment refractory heparin-induced thrombocytopenia. BMJ Case Reports. 2016:bcr2016216110-bcr2016216110. 2016
- Platelet function testing: does a randomized controlled trial settle the debate?. Journal of NeuroInterventional Surgery. 8:768-769. 2016
- Evolving Treatments for Arterial and Venous Thrombosis. Circulation Research. 118:1409-1424. 2016
- When and how to use antidotes for the reversal of direct oral anticoagulants: guidance from the SSC of the ISTH. Journal of Thrombosis and Haemostasis. 14:623-627. 2016
- Laboratory measurement of the direct oral anticoagulants. British Journal of Haematology. 172:315-336. 2016
- Effect of standardized perioperative dabigatran interruption on the residual anticoagulation effect at the time of surgery or procedure. Journal of Thrombosis and Haemostasis. 14:89-97. 2016
- Net benefit of ticagrelor in patients with chronic kidney disease. Nature Reviews Nephrology. 12:10-11. 2016
- Evaluating coagulation tests in patients with atrial fibrillation using direct oral anticoagulants. Expert Review of Cardiovascular Therapy. 13:1213-1223. 2015
- Timing the First Postoperative Dose of Anticoagulants. Chest. 148:587-595. 2015
- Dabigatran is Less Effective Than Warfarin at Attenuating Mechanical Heart Valve‐Induced Thrombin Generation. Journal of the American Heart Association. 4:e002322. 2015
- A systematic review of contemporary trials of anticoagulants in orthopaedic thromboprophylaxis: suggestions for a radical reappraisal. Journal of Thrombosis and Thrombolysis. 40:231-239. 2015
- Real-world variability in dabigatran levels in patients with atrial fibrillation: reply. Journal of Thrombosis and Haemostasis. 13:1168-1169. 2015
- Anatomical effects of clear lens extraction by phacoemulsification versus trabeculectomy on anterior chamber drainage angle in primary angle-closure glaucoma (PACG) patients. German journal of ophthalmology. 253:773-778. 2015
- Multiple daily doses of acetyl‐salicylic acid (ASA) overcome reduced platelet response to once‐daily ASA after coronary artery bypass graft surgery: a pilot randomized controlled trial. Journal of Thrombosis and Haemostasis. 13:448-456. 2015
- Real‐world variability in dabigatran levels in patients with atrial fibrillation. Journal of Thrombosis and Haemostasis. 13:353-359. 2015
- Lack of consistency in the relationship between asymptomatic DVT detected by venography and symptomatic VTE in thromboprophylaxis trials. Thrombosis and Haemostasis. 114:1049-1057. 2015
- Profile of betrixaban and its potential in the prevention and treatment of venous thromboembolism. Vascular Health and Risk Management. 11:343-343. 2015
- Role of phenotypic and genetic testing in managing clopidogrel therapy. Blood. 124:689-699. 2014
- Betrixaban (PRT054021): pharmacology, Dose Selection and Clinical Studies. Future Cardiology. 10:43-52. 2014
- Mandatory contrast-enhanced venography to detect deep-vein thrombosis (DVT) in studies of DVT prophylaxis: upsides and downsides. Thrombosis and Haemostasis. 111:10-13. 2014
- New oral anticoagulants for stroke prevention in atrial fibrillation: impact of study design, double counting and unexpected findings on interpretation of study results and conclusions. Thrombosis and Haemostasis. 112:798-807. 2014
- The Pathogenesis of Nonarteritic Anterior Ischemic Optic Neuropathy. Asia - Pacific Journal of Ophthalmology. 2:132-135. 2013
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How do we manage venous thromboembolism in pregnancy? A retrospective review of the practice of diagnosing and managing pregnancy‐related venous thromboembolism at two major hospitals in
A ustralia andN ewZ ealand. Internal Medicine Journal. 42:1104-1112. 2012 - MDS with del(5q) and associated cKIT D816V positive mastocytosis. Pathology. 44:492-493. 2012
- Acute and subacute inflammation of the optic nerve and its sheath: clinical features in Chinese patients.. Hong Kong Medical Journal. 18:115-122. 2012
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preprints