selected scholarly activity
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books
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conferences
- Estimating nutrient inadequacy of adult Inuit diets. The FASEB Journal. A96-A96. 2004
- Enzymatic transition state structures constrained by experimental kinetic isotope effect measurements.. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. U518-U518. 1998
- Transition state structures of ADP-ribosyltransferases from structure interpolation analysis of experimental kinetic isotope effects. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. U529-U529. 1998
- Enzymatic transition states and inhibitor design from principles of classical and quantum chemistry. International Journal of Quantum Chemistry. 1805-1813. 1996
- KINETIC ISOTOPE EFFECTS OF DIPHTHERIA TOXIN-CATALYZED NAD+ HYDROLYSIS. The FASEB Journal. A1281-A1281. 1994
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journal articles
- Role of Half-of-Sites Reactivity and Inter-Subunit Communications in DAHP Synthase Catalysis and Regulation. Biochemistry. 61:2229-2240. 2022
- An Inhibitor-in-Pieces Approach to DAHP Synthase Inhibition: Potent Enzyme and Bacterial Growth Inhibition. ACS Infectious Diseases. 7:3292-3302. 2021
- NeuNAc Oxime: A Slow-Binding and Effectively Irreversible Inhibitor of the Sialic Acid Synthase NeuB. Biochemistry. 58:4236-4245. 2019
- Eliminating Competition: Characterizing and Eliminating Competitive Binding at Separate Sites between DAHP Synthase’s Essential Metal Ion and the Inhibitor DAHP Oxime. Biochemistry. 57:6679-6687. 2018
- Campylobacter jejuni KDO8P Synthase, Its Inhibition by KDO8P Oxime, and Control of the Residence Time of Slow-Binding Inhibition. Biochemistry. 57:5327-5338. 2018
- 67 Ga-labeled deferoxamine derivatives for imaging bacterial infection: Preparation and screening of functionalized siderophore complexes. Nuclear Medicine and Biology. 52:32-41. 2017
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Linear Free Energy Relationship Analysis of Transition State Mimicry by 3-Deoxy-
d -arabino-heptulosonate-7-phosphate (DAHP) Oxime, a DAHP Synthase Inhibitor and Phosphate Mimic. Biochemistry. 56:592-601. 2017 - Correction: A 99mTc-Labelled Tetrazine for Bioorthogonal Chemistry. Synthesis and Biodistribution Studies with Small Molecule trans-Cyclooctene Derivatives. PLoS ONE. 12:e0171909-e0171909. 2017
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Potent Inhibition of 3-Deoxy-
d -arabinoheptulosonate-7-phosphate (DAHP) Synthase by DAHP Oxime, a Phosphate Group Mimic. Biochemistry. 55:6617-6629. 2016 - A 99mTc-Labelled Tetrazine for Bioorthogonal Chemistry. Synthesis and Biodistribution Studies with Small Molecule trans-Cyclooctene Derivatives. PLoS ONE. 11:e0167425-e0167425. 2016
- Transition State Analysis of Acid-Catalyzed Hydrolysis of an Enol Ether, Enolpyruvylshikimate 3-Phosphate (EPSP). Journal of the American Chemical Society. 134:12947-12957. 2012
- Transition State Analysis of Enolpyruvylshikimate 3-Phosphate (EPSP) Synthase (AroA)-Catalyzed EPSP Hydrolysis. Journal of the American Chemical Society. 134:12958-12969. 2012
- Measuring Dynamics in Weakly Structured Regions of Proteins Using Microfluidics-Enabled Subsecond H/D Exchange Mass Spectrometry. Analytical Chemistry. 84:3771-3779. 2012
- Lyme Disease Enolpyruvyl-UDP-GlcNAc Synthase: Fosfomycin-Resistant MurA from Borrelia burgdorferi, a Fosfomycin-Sensitive Mutant, and the Catalytic Role of the Active Site Asp. Biochemistry. 50:2205-2212. 2011
- Evidence of Kinetic Control of Ligand Binding and Staged Product Release in MurA (Enolpyruvyl UDP-GlcNAc Synthase)-Catalyzed Reactions,. Biochemistry. 48:11715-11723. 2009
- Catalytic Residues and an Electrostatic Sandwich That Promote Enolpyruvyl Shikimate 3-Phosphate Synthase (AroA) Catalysis. Biochemistry. 48:3699-3707. 2009
- Transition-State Analysis of the DNA Repair Enzyme MutY. Journal of the American Chemical Society. 130:5789-5797. 2008
- Transition State Analysis of Acid-Catalyzed dAMP Hydrolysis. Journal of the American Chemical Society. 129:7055-7064. 2007
- Enolpyruvyl Activation by Enolpyruvylshikimate-3-phosphate Synthase. Biochemistry. 46:1933-1940. 2007
- Toward a Detailed Understanding of Base Excision Repair Enzymes: Transition State and Mechanistic Analyses of N‐Glycoside Hydrolysis and N‐Glycoside Transfer. ChemInform. 37:no-no. 2006
- Implications of Protonation and Substituent Effects for C−O and O−P Bond Cleavage in Phosphate Monoesters. Journal of the American Chemical Society. 128:6132-6140. 2006
- Phosphate Analogues as Probes of the Catalytic Mechanisms of MurA and AroA, Two Carboxyvinyl Transferases. Biochemistry. 45:6027-6037. 2006
- Toward a Detailed Understanding of Base Excision Repair Enzymes: Transition State and Mechanistic Analyses of N-Glycoside Hydrolysis and N-Glycoside Transfer. Chemical Reviews. 106:506-555. 2006
- UDP-N-acetylmuramic Acid (UDP-MurNAc) Is a Potent Inhibitor of MurA (Enolpyruvyl-UDP-GlcNAc Synthase). Biochemistry. 44:4011-4017. 2005
- Probing the Transition States of Four Glucoside Hydrolyses with 13C Kinetic Isotope Effects Measured at Natural Abundance by NMR Spectroscopy. Journal of the American Chemical Society. 126:3769-3776. 2004
- Nonenzymatic Breakdown of the Tetrahedral (α-Carboxyketal Phosphate) Intermediates of MurA and AroA, Two Carboxyvinyl Transferases. Protonation of Different Functional Groups Controls the Rate and Fate of Breakdown. Journal of the American Chemical Society. 125:12541-12550. 2003
- Transition State Analysis Using Multiple Kinetic Isotope Effects: Mechanisms of Enzymatic and Non‐Enzymatic Glycoside Hydrolysis and Transfer. ChemInform. 34:no-no. 2003
- Adenine Release Is Fast in MutY-catalyzed Hydrolysis of G:A and 8-Oxo-G:A DNA Mismatches. Journal of Biological Chemistry. 278:29587-29592. 2003
- Identification of the catalytic residues of AroA (Enolpyruvylshikimate 3-phosphate synthase) using partitioning analysis. Biochemistry. 42:6986-6995. 2003
- Identification of the Catalytic Residues of AroA (Enolpyruvylshikimate 3-Phosphate Synthase) Using Partitioning Analysis. Biochemistry. 42:6986-6995. 2003
- Transition-state analysis for depurination of DNA by Ricin A-chain. Journal of the American Chemical Society. 122. 2000
- Transition-State Analysis for Depurination of DNA by Ricin A-Chain. Journal of the American Chemical Society. 122:6527-6534. 2000
- Ricin A-Chain: Kinetic Isotope Effects and Transition State Structure with Stem-Loop RNA. Journal of the American Chemical Society. 122:1609-1617. 2000
- Enzymatic Transition State Structures Constrained by Experimental Kinetic Isotope Effects: Experimental Measurement of Transition State Variability. ACS Symposium Series. 721:473-488. 1999
- [14] Determining transition states from kinetic isotope effects. Methods in Enzymology. 308:355-397. 1999
- Transition-State Structure for the ADP-Ribosylation of Recombinant Giα1 Subunits by Pertussis Toxin. Biochemistry. 37:2748-2758. 1998
- Transition State Structure for the Hydrolysis of NAD+Catalyzed by Diphtheria Toxin. Journal of the American Chemical Society. 119:12079-12088. 1997
- Transition State Structure of the Solvolytic Hydrolysis of NAD+. Journal of the American Chemical Society. 119:12069-12078. 1997
- Affinity Purification and Elimination of Methionine Oxidation in Recombinant Human Cystatin C. Protein Expression and Purification. 11:111-118. 1997
- Processing of the Papain Precursor. Journal of Biological Chemistry. 270:10838-10846. 1995
- Alignment/Phylogeny of the Papain Superfamily of Cysteine Proteases. Journal of Molecular Biology. 246:273-283. 1995
- Local pH-dependent conformational changes leading to proteolytic susceptibility of cystatin C. Biochemical Journal. 302:411-416. 1994
- Cooperativity of papain-substrate interaction energies in the S2 to S2' subsites. Biochemistry. 30:1394-1402. 1991
- Coordinated amino acid changes in homologous protein families. Protein Engineering, Design and Selection. 2:193-199. 1988