Journal article
Transcriptional effects of hypoxia on fusiogenic syncytin and its receptor ASCT2 in human cytotrophoblast BeWo cells and in ex vivo perfused placental cotyledons
Abstract
OBJECTIVE: The purpose of this study was to test the hypothesis that hypoxia down-regulates placental syncytin, which could play a role in altered placentogenesis; we investigated the influence of hypoxia on syncytin and its receptor ASCT2 gene expression in BeWo cells and in ex vivo perfused human cotyledons.
STUDY DESIGN: BeWo cells were incubated with deferoxamine or cobalt chloride under normoxia and hypoxia. Additionally, a model of dually …
Authors
Knerr I; Weigel C; Linnemann K; Dötsch J; Meißner U; Fusch C; Rascher W
Journal
American Journal of Obstetrics and Gynecology, Vol. 189, No. 2, pp. 583–588
Publisher
Elsevier
Publication Date
8 2003
DOI
10.1067/s0002-9378(03)00538-6
ISSN
0002-9378
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Amino Acid Transport System ASCCell LineCobaltComputer SystemsDeferoxamineDown-RegulationFemaleGene Products, envHumansHypoxiaIn Vitro TechniquesIron Chelating AgentsMinor Histocompatibility AntigensPlacentaPolymerase Chain ReactionPregnancyPregnancy ProteinsRNA, MessengerTranscription, GeneticTrophoblasts