Journal article
EPIDERMAL GROWTH FACTOR-MEDIATED ACTIVATION OF THE MAP KINASE CASCADE RESULTS IN ALTERED EXPRESSION AND FUNCTION OF ABCG2 (BCRP)
Abstract
Epidermal growth factor (EGF) is a multifunctional growth factor known to play a major role in proliferation and differentiation processes. EGF-induced differentiation is a prerequisite for function of various cell types, among them cytotrophoblasts, a functionally important cellular fraction in human placenta. Stimulation of cytotrophoblasts with EGF results in formation of a multinuclear syncytium representing the feto-maternal interface, …
Authors
Schwabedissen HEMZ; Grube M; Dreisbach A; Jedlitschky G; Meissner K; Linnemann K; Fusch C; Ritter CA; Völker U; Kroemer HK
Journal
Drug Metabolism and Disposition, Vol. 34, No. 4, pp. 524–533
Publisher
Elsevier
Publication Date
April 2006
DOI
10.1124/dmd.105.007591
ISSN
0090-9556
Fields of Research (FoR)
Medical Subject Headings (MeSH)
ATP Binding Cassette Transporter, Subfamily G, Member 2ATP-Binding Cassette TransportersAdultAntineoplastic AgentsCell LineCell Line, TumorCells, CulturedDose-Response Relationship, DrugDrug ResistanceEnzyme ActivationEpidermal Growth FactorExtracellular Signal-Regulated MAP KinasesFemaleGene Expression Regulation, DevelopmentalGestational AgeHumansJNK Mitogen-Activated Protein KinasesMAP Kinase Signaling SystemNeoplasm ProteinsPregnancyProtein Kinase InhibitorsRNA, MessengerTime FactorsTrophoblasts