Journal article
Gastric mucosal toxicity of duodenal juice constituents in the rat
Abstract
To determine the acute gastrotoxicity of refluxed duodenal contents, anex vivo rat gastric chamber was used to study mucosal damage produced by conjugated and unconjugated human bile acids and lysolecithin at neutral and acidic pH; the effects of trypsin, human duodenal aspirate, and combinations of chenodeoxycholic acid, lecithin, and lysolecithin were also studied. At neutral pH, all bile acids except tauroursodeoxycholic acid, caused …
Authors
Armstrong D; Rytina ERC; Murphy GM; Dowling RH
Journal
Digestive Diseases and Sciences, Vol. 39, No. 2, pp. 327–339
Publisher
Springer Nature
Publication Date
2 1994
DOI
10.1007/bf02090205
ISSN
0163-2116