Bone marrow events in animal models of allergic inflammation and hyperresponsiveness

Allergic inflammation is associated with the marked infiltration of eosinophils in affected tissues. Eosinophilia, in turn, is a hallmark clinical feature associated with allergic rhinitis, atopic dermatitis, sinusitis, and asthma. There is considerable evidence in animal models and humans that the bone marrow plays an integral role in allergic inflammation. Evidence shows that, in response to allergen exposure in the airway, bone marrow (white …