Journal article
Dystrophin isoforms Dp71 and Dp427 have distinct roles in myogenic cells
Abstract
Duchenne muscular dystrophy is caused by mutations in the dystrophin gene, a complex gene that generates a family of distinct isoforms. In immature muscle cells, two dystrophin isoforms are expressed, Dp427 and Dp71. To characterize the function of Dp71 in myogenesis, we have examined the expression of Dp71 in myogenic cells. The localization of Dp71 in these cells is distinct from the localization of Dp427. Whereas Dp427 localizes to focal …
Authors
Howard PL; Dally GY; Ditta SD; Austin RC; Worton RG; Klamut HJ; Ray PN
Journal
Muscle & Nerve, Vol. 22, No. 1, pp. 16–27
Publisher
Wiley
Publication Date
January 1999
DOI
10.1002/(sici)1097-4598(199901)22:1<16::aid-mus5>3.0.co;2-r
ISSN
0148-639X
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
ActinsAnimalsBlotting, WesternCell LineCells, CulturedDystrophinFetusGene Expression Regulation, DevelopmentalGreen Fluorescent ProteinsHumansLuminescent ProteinsMiceMicroscopy, FluorescenceMuscle, SkeletalProtein IsoformsRecombinant Fusion ProteinsReverse Transcriptase Polymerase Chain ReactionSubcellular FractionsTransfection