Journal article
Safety Outcomes in Meta-analyses of Phase 2 vs Phase 3 Randomized Trials: Intracranial Hemorrhage in Trials of Bolus Thrombolytic Therapy
Abstract
CONTEXT: Recent studies have reported disagreement between meta-analysis of small trials and subsequent large trials addressing the same question. However, disagreement for uncommon but serious adverse safety outcomes has not been examined.
OBJECTIVE: To explore disagreement for serious adverse safety (intracranial hemorrhage [ICH]) and efficacy outcomes between meta-analysis of phase 2 (small) vs meta-analysis of phase 3 (large) randomized …
Authors
Eikelboom JW; Mehta SR; Pogue J; Yusuf S
Journal
JAMA: The Journal of the American Medical Association, Vol. 285, No. 4, pp. 444–450
Publisher
American Medical Association (AMA)
Publication Date
January 24, 2001
DOI
10.1001/jama.285.4.444
ISSN
0098-7484