Journal article
Bone recognition mechanism of porcine osteocalcin from crystal structure
Abstract
Osteocalcin is the most abundant noncollagenous protein in bone1, and its concentration in serum is closely linked to bone metabolism and serves as a biological marker for the clinical assessment of bone disease2. Although its precise mechanism of action is unclear, osteocalcin influences bone mineralization3,4, in part through its ability to bind with high affinity to the mineral component of bone, hydroxyapatite5. In addition to binding to …
Authors
Hoang QQ; Sicheri F; Howard AJ; Yang DSC
Journal
Nature, Vol. 425, No. 6961, pp. 977–980
Publisher
Springer Nature
Publication Date
October 2003
DOI
10.1038/nature02079
ISSN
0028-0836