Validation of pH Dataloggers for Pharmacologic Studies

Twenty-four-hour gastric aspiration studies have been superseded by dataloggers that continuously record intragastric pH. We have studied both techniques in a practical pharmacologic study, comparing early evening versus nighttime dosing with ranitidine and nizatidine against placebo. Whereas there was a highly significant point correlation between aspiration and datalogger pH, the slope was significantly less than 1. The correlation was poorer …