Serotonin re-uptake inhibitors in the treatment of premenstrual dysphoria: Current state of knowledge

Late luteal phase dysphoric disorder (LLPDD) and the more recently introduced premenstrual dysphoric disorder (PMDD) are recognized psychiatric disorders that consist of distressing emotional and behavioural symptoms that occur premenstrually. Recently, advances have been made in understanding the aetiology of the disorder, with clear evidence to implicate the serotonergic system. In women with predominately psychological symptoms, selective serotonin re-uptake inhibitors (SSRIs), as well as clomipramine, have demonstrated excellent efficacy and minimal side effects.