Journal article
Effects of peroxynitrite on sarcoplasmic reticulum Ca2+ pump in pig coronary artery smooth muscle
Abstract
Peroxynitrite generated in arteries from superoxide and NO may damage Ca(2+) pumps. Here, we report the effects of peroxynitrite on ATP-dependent azide-insensitive uptake of Ca(2+) into pig coronary artery vesicular membrane fractions F2 [enriched in plasma membrane (PM)] and F3 [enriched in sarcoplasmic reticulum (SR)]. Membranes were pretreated with peroxynitrite and then with DTT to quench this agent. This pretreatment inhibited Ca(2+) …
Authors
Grover AK; Samson SE; Robinson S; Kwan CY
Journal
American Journal of Physiology - Cell Physiology, Vol. 284, No. 2, pp. c294–c301
Publisher
American Physiological Society
Publication Date
February 1, 2003
DOI
10.1152/ajpcell.00297.2002
ISSN
0363-6143
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Acid Anhydride HydrolasesAdenosine TriphosphateAnimalsCalcium SignalingCalcium-Transporting ATPasesCation Transport ProteinsCell MembraneCoronary Artery DiseaseCoronary VesselsDithiothreitolDose-Response Relationship, DrugEnzyme InhibitorsMuscle, Smooth, VascularOxidative StressPeroxynitrous AcidPlasma Membrane Calcium-Transporting ATPasesReactive Oxygen SpeciesReperfusion InjurySarcoplasmic ReticulumSarcoplasmic Reticulum Calcium-Transporting ATPasesSubcellular FractionsSus scrofaAcylphosphatase