Journal article
DRB resistance in Chinese hamster and human cells: Genetic and biochemical characteristics of the selection system
Abstract
Stable mutants resistant to the nucleoside analog 5,6-dichloro-1-β-d-ribofuranosyl benzimidazole (DRB), which interferes with RNA synthesis, have been selected in Chinese hamster ovary (CHO) and human diploid fibroblasts. In CHO cells, upon treatment with the mutagen ethylmethane sulfonate (EMS), a linear dose—response between the concentration of mutagen and the frequency of DrbR mutants was observed in the range of 20–300 μg/ml. The selection …
Authors
Gupta RS; Siminovitch L
Journal
Somatic Cell Genetics, Vol. 6, No. 2, pp. 151–169
Publisher
Springer Nature
Publication Date
March 1980
DOI
10.1007/bf01538793
ISSN
0098-0366