Journal article
An oral melatonin replacement regimen that re‐establishes the normal circadian levels of urinary 6‐sulphatoxymelatonin in functionally pinealectomized rats
Abstract
Wistar rats maintained on a 12-hr daily photoperiod (LD 12:12 cycle) exhibited a diurnal rhythm in urinary 6-sulphatoxymelatonin (aMT6s) concentrations with peak levels in the scotophase. Light-induced functional pinealectomy (FPX) abolished the nocturnal rise in aMT6s, lowering it to photophase levels. The objective of the study was to formulate an oral melatonin replacement regimen that would restore a normal rhythmic output of urinary aMT6s …
Authors
John TM; Brown MC; Brown GM
Journal
Journal of Pineal Research, Vol. 13, No. 4, pp. 145–150
Publisher
Wiley
Publication Date
November 1992
DOI
10.1111/j.1600-079x.1992.tb00069.x
ISSN
0742-3098