Journal article
The Effect of Paroxetine on 5-HT2A Receptors in Depression: An 18FSetoperone PET Imaging Study
Abstract
OBJECTIVE: In the cortex of animals, serotonin (5-HT) levels increase after several weeks of treatment with selective serotonin reuptake inhibitors (SSRIs). Studies using an intrasubject design to examine the effects of SSRI treatment on 5-HT(2A) receptors in the cortex of drug-free depressed patients are needed. In theory, agonist stimulation of 5-HT(2A) receptors could be relevant to SSRI treatment by promoting neuronal growth and survival as …
Authors
Meyer JH; Kapur S; Eisfeld B; Brown GM; Houle S; DaSilva J; Wilson AA; Rafi-Tari S; Mayberg HS; Kennedy SH
Journal
American Journal of Psychiatry, Vol. 158, No. 1, pp. 78–85
Publisher
American Psychiatric Association Publishing
Publication Date
January 1, 2001
DOI
10.1176/appi.ajp.158.1.78
ISSN
0002-953X