Journal article
Mechanisms of action of cholecystokinin in the canine gastrointestinal tract: role of vasoactive intestinal peptide and nitric oxide.
Abstract
This study defined the cholecystokinin (CCK)/gastrin receptor subtypes at which CCK octapeptide (CCK8) and gastrin 17 (G17)act on motor functions of the intact canine gastrointestinal tract. In the antrum, studies of tachyphylaxis and effects of antagonists showed that i.a. G17 acted through CCKB receptors to activate contractions, whereas CCK8 acted through A and B receptor subtypes to produce contractions. In the duodenum, i.a. G17 caused …
Authors
Vergara P; Woskowska Z; Cipris S; Fox-Threlkeld JE; Daniel EE
Journal
Journal of Pharmacology and Experimental Therapeutics, Vol. 279, No. 1, pp. 306–316
Publisher
Elsevier
Publication Date
October 1996
DOI
10.1016/s0022-3565(25)20969-7
ISSN
0022-3565