Journal article
The shortest telomeres drive karyotype evolution in transformed cells
Abstract
Maintenance of telomeres is essential for chromosome stability. In the absence of telomerase, telomeres shorten with cell division until they approach a stability threshold, at which point cells enter senescence. When senescence-signaling pathways are inactive, further telomere shortening leads to chromosome instability characterized by telomeric fusions and breakage-fusion-bridge (BFB) cycles. Since the distribution of telomere lengths among …
Authors
der-Sarkissian H; Bacchetti S; Cazes L; Londoño-Vallejo JA
Journal
Oncogene, Vol. 23, No. 6, pp. 1221–1228
Publisher
Springer Nature
Publication Date
February 12, 2004
DOI
10.1038/sj.onc.1207152
ISSN
0950-9232