Journal article
The role of iron in the toxicity of 2,3,7,8-tetrachlorodibenzo-(p)-dioxin (TCDD)
Abstract
The effects of TCDD on normal and iron-deficient mice fed a casein-based diet were compared. Liver damage, porphyria, and thymic atrophy were studied in C57B1/6J mice, chloracne and liver damage in the HRS/J strain. Sequential pathologic changes also were studied in C57B1/6J mice fed laboratory chow and treated with TCDD (25 μg/kg/week). Steatosis was present by Day 4; cell swelling, necrosis, and disorganization of the acinar architecture …
Authors
Jones KG; Cole FM; Sweeney GD
Journal
Toxicology and Applied Pharmacology, Vol. 61, No. 1, pp. 74–88
Publisher
Elsevier
Publication Date
10 1981
DOI
10.1016/0041-008x(81)90009-0
ISSN
0041-008X