Journal article
Monitoring unfractionated heparin with the aPTT: Time for a fresh look
Abstract
Laboratory monitoring is widely recommended to measure the anticoagulant effect of unfractionated heparin and to adjust the dose to maintain levels in the target therapeutic range. The most widely used laboratory assay for monitoring unfractionated heparin therapy is the activated partial thromboplastin time (aPTT). A fixed therapeutic range for the aPTT of 1.5 to 2.5 times the control value has become widely accepted, but the evidence …
Authors
Eikelboom JW; Hirsh J
Journal
Thrombosis and Haemostasis, Vol. 96, No. 05, pp. 547–552
Publisher
Thieme
Publication Date
2006
DOI
10.1160/th06-05-0290
ISSN
0340-6245