Journal article
Early stopping of randomized clinical trials for overt efficacy is problematic
Abstract
OBJECTIVE: To illustrate controversial issues associated with stopping randomized controlled trials (RCTs) early for apparent benefit.
STUDY DESIGN AND SETTING: The article presents our review of prior relevant work and our research group's reflections on early stopping.
Authors
Bassler D; Montori VM; Briel M; Glasziou P; Guyatt G
Journal
Journal of Clinical Epidemiology, Vol. 61, No. 3, pp. 241–246
Publisher
Elsevier
Publication Date
3 2008
DOI
10.1016/j.jclinepi.2007.07.016
ISSN
0895-4356