Journal article
Vitamin K antagonists in heart disease: Current status and perspectives (Section III)
Abstract
Oral anticoagulants are a mainstay of cardiovascular therapy, and for over 60 years vitamin K antagonists (VKAs) were the only available agents for long-term use. VKAs interfere with the cyclic inter-conversion of vitamin K and its 2,3 epoxide, thus inhibiting γ-carboxylation of glutamate residues at the amino-termini of vitamin K-dependent proteins, including the coagulation factors (F) II (prothrombin), VII, IX and X, as well as of the …
Authors
De Caterina R; Husted S; Wallentin L; Andreotti F; Arnesen H; Bachmann F; Baigent C; Huber K; Jespersen J; Kristensen SD
Journal
Thrombosis and Haemostasis, Vol. 110, No. 06, pp. 1087–1107
Publisher
Thieme
Publication Date
2013
DOI
10.1160/th13-06-0443
ISSN
0340-6245