Journal article
A Novel Mechanism of Rapid Nuclear Neutrophil Extracellular Trap Formation in Response to Staphylococcus aureus
Abstract
Neutrophil extracellular traps (NETs) are webs of DNA covered with antimicrobial molecules that constitute a newly described killing mechanism in innate immune defense. Previous publications reported that NETs take up to 3-4 h to form via an oxidant-dependent event that requires lytic death of neutrophils. In this study, we describe neutrophils responding uniquely to Staphylococcus aureus via a novel process of NET formation that did not …
Authors
Pilsczek FH; Salina D; Poon KKH; Fahey C; Yipp BG; Sibley CD; Robbins SM; Green FHY; Surette MG; Sugai M
Journal
The Journal of Immunology, Vol. 185, No. 12, pp. 7413–7425
Publisher
Oxford University Press (OUP)
Publication Date
December 15, 2010
DOI
10.4049/jimmunol.1000675
ISSN
0022-1767