Journal article
Fluvastatin Causes NLRP3 Inflammasome-Mediated Adipose Insulin Resistance
Abstract
Statins reduce lipid levels and are widely prescribed. Statins have been associated with an increased incidence of type 2 diabetes, but the mechanisms are unclear. Activation of the NOD-like receptor family, pyrin domain containing 3 (NLRP3)/caspase-1 inflammasome, promotes insulin resistance, a precursor of type 2 diabetes. We showed that four different statins increased interleukin-1β (IL-1β) secretion from macrophages, which is …
Authors
Henriksbo BD; Lau TC; Cavallari JF; Denou E; Chi W; Lally JS; Crane JD; Duggan BM; Foley KP; Fullerton MD
Journal
Diabetes, Vol. 63, No. 11, pp. 3742–3747
Publisher
American Diabetes Association
Publication Date
November 1, 2014
DOI
10.2337/db13-1398
ISSN
0012-1797