An AMP-activated protein kinase–stabilizing...

An AMP-activated protein kinase–stabilizing peptide ameliorates adipose tissue wasting in cancer cachexia in mice

Abstract

Cancer cachexia is marked by a pathological loss of fat tissue, but preventing the degradation of AMPK in this tissue helps preserve its mass in mouse models.

Authors

Rohm M; Schäfer M; Laurent V; Üstünel BE; Niopek K; Algire C; Hautzinger O; Sijmonsma TP; Zota A; Medrikova D

Journal

Nature Medicine, Vol. 22, No. 10, pp. 1120–1130

Publisher

Springer Nature

Publication Date

October 1, 2016

DOI

10.1038/nm.4171

ISSN

1078-8956

Associated Experts

Gregory Steinberg

Professor, Faculty of Health Sciences

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