Journal article
Retinoic acid- and staurosporine-induced bidirectional differentiation of human neuroblastoma cell lines
Abstract
The differentiation pattern of two related human neuroblastoma cell lines, SK-N-SHF and SK-N-SHN, induced by retinoic acid and staurosporine was studied. Immunohistochemical and electron microscopic examination of the cells indicated that the SHF variant could undergo differentiation along a melanocytic route when treated with retinoic acid and to neuronal cells when treated with retionic acid and staurosporine together. Treatment of SHN cells …
Authors
Slack R; Lach B; Gregor A; Al-Mazidi H; Proulx P
Journal
Experimental Cell Research, Vol. 202, No. 1, pp. 17–27
Publisher
Elsevier
Publication Date
September 1992
DOI
10.1016/0014-4827(92)90399-s
ISSN
0014-4827