Effects of intravenously administered enantiomers of baclofen on functionally identified units in lumbar dorsal horn of the spinal cat

The present study investigated the effects of intravenous administration of the d- and l-enantiomers of baclofen on extracellular single unit spikes recorded from the lumbar dorsal horn of the spinalized cat, either anaesthetized with chloralose or decerebrated. Both enantiomers had two types of depressant effect. One was a transient (complete within 2 min), non-specific depression of the discharge of synaptically-elicited responses and of the …