Journal article
Elaboration of silica colloid/polymer hybrid support for oligonucleotide synthesis
Abstract
One way to increase the sensitivity of DNA diagnostic assays developed on microarrays is to improve the solid phase that allows the extraction of the target from a biological sample, before detection. Two parameters are influencing the performances of this capture step: (i) the specific surface area being offered for the capture and (ii) the number and the accessibility of oligonucleotide probes immobilized on the surface. In this context, we …
Authors
Pacard E; Brook MA; Ragheb AM; Pichot C; Chaix C
Journal
Colloids and Surfaces B Biointerfaces, Vol. 47, No. 2, pp. 176–188
Publisher
Elsevier
Publication Date
2 2006
DOI
10.1016/j.colsurfb.2005.12.008
ISSN
0927-7765