Journal article
On the Pharmacological and Physiological Role of Glibenclamide‐Sensitive Potassium Channels in Colonic Smooth Muscle
Abstract
Actions of activators of glibenclamide sensitive K+ channels on canine colonic circular muscle were investigated. Cromakalim as well as its (-) enantiomer lemakalim caused inhibition of spontaneous phasic contractile activity (EC50's 4.4 +/- 0.1 x 10(-7) M and 2.3 +/- 0.4 x 10(-7) M, respectively) and of carbachol induced activity (EC50's: 9.4 +/- 5.1 x 10(-7) M and 4.3 +/- 1.4 x 10(-7) M, respectively). Cromakalim and lemakalim effects were …
Authors
Richardson D; Alibhai KN; Huizinga JD
Journal
Basic & Clinical Pharmacology & Toxicology, Vol. 71, No. 5, pp. 365–370
Publisher
Wiley
Publication Date
11 1992
DOI
10.1111/j.1600-0773.1992.tb00563.x
ISSN
1742-7835