Journal article
Gastrointestinal Stromal Tumors May Originate from a Subset of CD34-Positive Interstitial Cells of Cajal
Abstract
Most gastrointestinal stromal tumors (GISTs), a subgroup of mesenchymal neoplasms of the gut wall, express both Kit (CD117) and CD34 proteins. It has been suggested that GISTs originate from or differentiate into interstitial cells of Cajal (ICC), after several reports indicated that ICC are likely the only cells in the gut which express both Kit and CD34. ICC are among the few cell types resident in the gut which express Kit, together with …
Authors
Robinson TL; Sircar K; Hewlett BR; Chorneyko K; Riddell RH; Huizinga JD
Journal
American Journal Of Pathology, Vol. 156, No. 4, pp. 1157–1163
Publisher
Elsevier
Publication Date
April 2000
DOI
10.1016/s0002-9440(10)64984-x
ISSN
0002-9440